US 12,458,615 B2
Methods for providing rapid relief of motor fluctuations in a Parkinson's disease patient
Richard P. Batycky, Newton, MA (US); Michael M. Lipp, Framingham, MA (US); and Martin Freed, Wellesley, MA (US)
Assigned to Merz Pharmaceuticals, LLC, Raleigh, NC (US)
Filed by Merz Pharmaceuticals, LLC, Raleigh, NC (US)
Filed on Nov. 15, 2024, as Appl. No. 18/949,037.
Application 18/949,037 is a continuation of application No. 18/593,291, filed on Mar. 1, 2024, abandoned.
Application 18/593,291 is a continuation of application No. 18/223,123, filed on Jul. 18, 2023, abandoned.
Application 18/223,123 is a continuation of application No. 18/076,575, filed on Dec. 7, 2022, abandoned.
Application 18/076,575 is a continuation of application No. 17/736,208, filed on May 4, 2022, abandoned.
Application 17/736,208 is a continuation of application No. 17/482,603, filed on Sep. 23, 2021, abandoned.
Application 17/482,603 is a continuation of application No. 17/173,564, filed on Feb. 11, 2021, abandoned.
Application 17/173,564 is a continuation of application No. 16/922,276, filed on Jul. 7, 2020, abandoned.
Application 16/922,276 is a continuation of application No. 16/688,274, filed on Nov. 19, 2019, abandoned.
Application 16/688,274 is a continuation of application No. 16/377,496, filed on Apr. 8, 2019, abandoned.
Application 16/377,496 is a continuation of application No. 16/114,434, filed on Aug. 28, 2018, abandoned.
Application 16/114,434 is a continuation of application No. 15/801,665, filed on Nov. 2, 2017, abandoned.
Application 15/801,665 is a continuation of application No. 14/691,793, filed on Apr. 21, 2015, abandoned.
Application 14/691,793 is a continuation of application No. PCT/US2013/065838, filed on Oct. 21, 2013.
Claims priority of provisional application 61/813,725, filed on Apr. 19, 2013.
Claims priority of provisional application 61/813,605, filed on Apr. 18, 2013.
Claims priority of provisional application 61/716,740, filed on Oct. 22, 2012.
Prior Publication US 2025/0248960 A1, Aug. 7, 2025
Int. Cl. A61K 31/198 (2006.01); A61K 9/00 (2006.01); A61K 31/197 (2006.01); A61K 45/06 (2006.01); A61K 9/16 (2006.01)
CPC A61K 31/198 (2013.01) [A61K 9/007 (2013.01); A61K 31/197 (2013.01); A61K 45/06 (2013.01); A61K 9/0075 (2013.01); A61K 9/0078 (2013.01); A61K 9/008 (2013.01); A61K 9/1617 (2013.01)] 18 Claims
 
1. A method of providing rapid relief of motor fluctuations in a Parkinson's disease patient comprising:
administering at least one fine particle dose (FPD) of 20 mg to 50 mg of levodopa by inhalation to a Parkinson's disease patient, said FPD comprising 90% by dry weight levodopa, 8% by dry weight dipalmitoyl phosphatidylcholine (DPPC) and 2% by dry weight sodium chloride and the particles of the FPD having an aerodynamic diameter of less than 5.6 μm;
wherein within about 10 minutes of administration of levodopa by inhalation, the patient's plasma levodopa concentration increases by at least about 200 ng/ml but no more than about 1000 ng/ml as compared to the patient's plasma levodopa concentration prior to administration; and
wherein said patient's plasma levodopa concentration maintains said increase of at least about 200 ng/ml for a time period of at least about 15 minutes after administration.