	US 12,458,602 B2
	Realizing the nano-amorphous state of materials inside nano-porous templates
Lei Xu, Hong Kong (CN); David Weitz, Bolton, MA (US); Zhuo Xu, Guangzhou (CN); and Changliang Zhu, Yantai (CN)
Assigned to The Chinese University of Hong Kong, Hong Kong (CN); and President and Fellows of Harvard College, Cambridge, MA (US)
Filed by The Chinese University of Hong Kong, Hong Kong (CN); and President and Fellows of Harvard College, Cambridge, MA (US)
Filed on May 6, 2021, as Appl. No. 17/313,528.
Prior Publication US 2022/0354796 A1, Nov. 10, 2022
Int. Cl. A61K 9/20 (2006.01); A61K 45/06 (2006.01)

CPC A61K 9/2095 (2013.01) [A61K 9/2009 (2013.01); A61K 9/2027 (2013.01); A61K 9/2031 (2013.01); A61K 9/2072 (2013.01); A61K 45/06 (2013.01)]

9 Claims

1. A method for producing nano-amorphous composite materials, the method comprising:

i) providing an active compound;

ii) providing a porous template made by agglomerating silica nanoparticles in an aqueous colloidal suspension and drying to preserve the porous template in dry conditions;

iii) melting, grinding, suspending, or dissolving the active compound in a solution to yield a ground active compound, a melted active compound, a suspended active compound, or a dissolved active compound;

iv) loading the ground active compound, melted active compound, dissolved active compound, or suspended active compound into the porous template to form an active compound loaded template;

v) pressing the active compound loaded porous template; and

vi) heating the active compound loaded porous template to form a composite material of the active compound absorbed in pores of the agglomerated silica nanoparticles wherein all of the active compound is in an amorphous state.