	US 12,458,601 B2
	Tamper-resistant drug dosage forms and methods of making and use thereof
Reza A. Fassihi, Fort Washington, PA (US)
Assigned to Temple University-Of The Commonwealth System of Higher Education, Philadelphia, PA (US)
Appl. No. 17/284,746
Filed by Temple University—Of The Commonwealth System of Higher Education, Philadelphia, PA (US)
PCT Filed Oct. 17, 2019, PCT No. PCT/US2019/056652 § 371(c)(1), (2) Date Apr. 12, 2021, PCT Pub. No. WO2020/081762, PCT Pub. Date Apr. 23, 2020.
Claims priority of provisional application 62/747,680, filed on Oct. 19, 2018.
Prior Publication US 2021/0322321 A1, Oct. 21, 2021
Int. Cl. A61K 9/20 (2006.01); A61K 9/28 (2006.01); A61K 45/06 (2006.01)

CPC A61K 9/204 (2013.01) [A61K 9/2027 (2013.01); A61K 9/2095 (2013.01); A61K 9/2893 (2013.01); A61K 45/06 (2013.01)]

8 Claims

1. A drug dosage form comprising:

a matrix polymer selected from the group consisting of polypropylene oxide, polyethylene oxide, polymethylene oxide, and mixtures, co-polymers, block co-polymers thereof;

a scaffold polymer comprising polyvinylpyrrolidone and polyvinyl acetate; and

a therapeutic agent;

wherein the mass ratio of matrix polymer to scaffold polymer is about 4:1 to 3:1; and

wherein the porosity of the drug dosage form is less than about 10%.