US 12,458,599 B2
Bioactivatable devices and related methods
Ulf Fritz, Bargen (CH); and Marc Gianotti, Wiesendangen (CH)
Assigned to CTI Vascular AG, Neuhausen (CH)
Appl. No. 18/248,025
Filed by CTI Vascular AG, Neuhausen (CH)
PCT Filed Sep. 30, 2021, PCT No. PCT/EP2021/076987
§ 371(c)(1), (2) Date Apr. 5, 2023,
PCT Pub. No. WO2022/073850, PCT Pub. Date Apr. 14, 2022.
Claims priority of provisional application 63/088,534, filed on Oct. 7, 2020.
Prior Publication US 2023/0270680 A1, Aug. 31, 2023
Int. Cl. A61K 9/16 (2006.01); A61K 33/04 (2006.01); A61K 33/24 (2019.01); A61L 27/02 (2006.01); A61L 27/30 (2006.01); A61L 27/54 (2006.01); A61L 31/08 (2006.01)
CPC A61K 9/167 (2013.01) [A61K 33/04 (2013.01); A61K 33/24 (2013.01); A61L 27/025 (2013.01); A61L 27/306 (2013.01); A61L 31/088 (2013.01); A61L 2300/10 (2013.01); A61L 2300/608 (2013.01); A61L 2420/08 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A material composition suitable for use as a bioactivatable coating for an implantable medical device, said composition comprising one or more transition metal chalcogenides provided in a non-bioactive form that are converted into a charged bioactive form upon exposure to physiological conditions, wherein said one or more transition metal chalcogenides are defined by Formula I:
MxAyBz  (Formula I)
having an index number x, y, and z that each constitute a non-zero atomic ratio of the material composition in which:
M is a transition metal element, further wherein M is molybdenum present in an atomic ratio x is 1 or 3;
A is a first chalcogenide element, further wherein A is sulfur present in an atomic ratio y, which is greater than 0 and less than or equal to 9;
B is a second chalcogenide element selected from the group consisting of oxygen and selenium, further wherein B is present in an atomic ratio z, which is greater than 0 and less than or equal to 9; and
wherein a sum of the atomic ratios y and z of the first and second chalcogenide elements A and B is non-stoichiometric and differs in a range from 0.01 to 20% from a corresponding stoichiometric sum that is sum defined as 2, 3, or 9, and wherein further, the material composition includes titanium, wherein an atomic ratio of Ti:M is in the range of 0.01 to 20%.