	US 12,458,587 B2
	*Hypoallergenic composition for skin regeneration or skin soothing, containing culture product or extract of Aureobasidium pullulans* strain**
Hohyun Song, Yongin-si (KR); and Kilsun Myoung, Yongin-si (KR)
Assigned to AMOREPACIFIC CORPORATION, Seoul (KR)
Appl. No. 17/290,965
Filed by AMOREPACIFIC CORPORATION, Seoul (KR)
PCT Filed Nov. 7, 2019, PCT No. PCT/KR2019/015077 § 371(c)(1), (2) Date May 3, 2021, PCT Pub. No. WO2020/096379, PCT Pub. Date May 14, 2020.
Claims priority of application No. 10-2018-0137527 (KR), filed on Nov. 9, 2018.
Prior Publication US 2022/0040085 A1, Feb. 10, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 8/99 (2017.01); A61Q 19/00 (2006.01); C12N 1/14 (2006.01); C12N 15/90 (2006.01); C12R 1/645 (2006.01)

CPC A61K 8/99 (2013.01) [A61Q 19/005 (2013.01); C12N 1/145 (2021.05); C12N 15/90 (2013.01); A61K 2800/72 (2013.01); C12R 2001/645 (2021.05)]

5 Claims

1. A method for relieving skin irritation caused by an α-hydroxy acid comprising:

applying a composition to a subject in need thereof comprising an amount effective for relieving skin irritation caused by the α-hydroxy acid and regenerating the skin, the composition including an extract of a culture product of an Aureobasidium pullulans strain, wherein the method relieves the skin irritation caused by the α-hydroxy acid by inhibiting an increase in an IL-1α concentration by the α-hydroxy acid, the strain of the culture product is Aureobasidium pullulans GJW with the accession number KCCM12142P, and wherein the extract of the culture product is an ethanol fraction of a culture fluid.