US 12,458,529 B2
Method and apparatuses for manipulating an endocrine body-temperature set-point in humans and warm-blooded animals
James Burgess, Missouri City, TX (US)
Filed by James Burgess, Missouri City, TX (US)
Filed on Feb. 28, 2023, as Appl. No. 18/115,183.
Application 18/115,183 is a continuation in part of application No. 17/552,248, filed on Dec. 15, 2021, abandoned.
Prior Publication US 2023/0201029 A1, Jun. 29, 2023
Int. Cl. A61F 7/12 (2006.01); A61F 7/00 (2006.01)
CPC A61F 7/12 (2013.01) [A61F 2007/0006 (2013.01); A61F 2007/0059 (2013.01); A61F 2007/0095 (2013.01); A61F 2007/126 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A method for manipulating an endocrine body temperature set-point in a human or a warm-blooded animal, the method comprises:
providing a guide tube, the guide tube is of a hollow tubular profile, the guide tube has a proximal end and a distal end, a proximal end portion of the guide tube is pre-formed to have a directional bend;
inserting the guide tube at the proximal end, through a nostril into a nasal cavity in proximity to sphenoid sinuses of a subject;
upon inserting the guide tube, inserting a catheter through the guide tube, wherein a leading end of the catheter is positioned over the sphenoid sinuses, wherein the directional bend of the guide tube is configured to direct the leading end of the catheter over the sphenoid sinuses;
applying a heat exchange medium, through the catheter, at a predetermined temperature selectively to the sphenoid sinuses for a predetermined duration to manipulate a temperature of a pituitary gland without manipulating a temperature of a hypothalamus; and
detecting an endocrine metabolic response in response to the application of the heat exchange medium.