US 12,458,515 B2
Endobronchial implants and related technology
Martin L. Mayse, Wayzata, MN (US); Karun D. Naga, Los Altos, CA (US); Hanson S. Gifford, III, Woodside, CA (US); Steven W. Kim, Los Altos, CA (US); Michael Hendricksen, Redwood City, CA (US); Douglas S. Sutton, Pacifica, CA (US); Nifer Beth Goldman, Redwood City, CA (US); Patrick P. Wu, San Carlos, CA (US); and Jagannath Padmanabhan, San Carlos, CA (US)
Assigned to Apreo Health, Inc., Menlo Park, CA (US)
Filed by Apreo Health, Inc., Menlo Park, CA (US)
Filed on Mar. 4, 2025, as Appl. No. 19/070,355.
Application 19/070,355 is a continuation of application No. 18/544,215, filed on Dec. 18, 2023, granted, now 12,285,345.
Application 18/544,215 is a continuation of application No. PCT/US2022/073962, filed on Jul. 20, 2022.
Claims priority of provisional application 63/268,604, filed on Feb. 27, 2022.
Claims priority of provisional application 63/223,546, filed on Jul. 20, 2021.
Prior Publication US 2025/0241773 A1, Jul. 31, 2025
Int. Cl. A61F 2/88 (2006.01); A61F 2/04 (2013.01); A61F 2/82 (2013.01); A61F 2/86 (2013.01)
CPC A61F 2/88 (2013.01) [A61F 2/04 (2013.01); A61F 2/82 (2013.01); A61F 2/86 (2013.01); A61F 2002/043 (2013.01); A61F 2002/825 (2013.01)] 30 Claims
OG exemplary drawing
 
1. An implant configured to be deployed at a treatment location in a bronchial airway of a human subject, the implant comprising:
a proximal portion and a distal portion spaced apart from the proximal portion along a longitudinal axis of the implant, wherein the proximal portion is configured to be positioned in a proximal region of the bronchial airway and the distal portion is configured to be positioned in a distal region of the bronchial airway, the distal region comprising a greater generation than the proximal region; and
a single wire extending along a continuous helical wire path comprising a series of contiguous turns between a proximal terminus of the wire at the proximal portion of the implant and a distal terminus of the wire at the distal portion of the implant, with a continuous opening defined between turns of the wire path and extending from the proximal terminus to the distal terminus,
wherein each turn of the wire path comprises first and second legs alternatingly disposed along the wire path with the first legs extending distally and the second legs pointing proximally, wherein at least one first leg and at least one second leg meet at an apex portion that points in a longitudinal direction along the longitudinal axis, and
wherein the implant is configured to resiliently transition from a low-profile delivery state to an expanded unconstrained state, wherein when the implant is in the expanded unconstrained state, the distal portion of the implant has a first average diameter and the proximal portion of the implant has a second average diameter, wherein the implant is configured such that a ratio of the first average diameter to an average native diameter of the distal region of the bronchial airway is greater than a ratio of the second average diameter to an average native diameter of the proximal region of the bronchial airway.