US 12,458,434 B2
Treatment of the reproductive tract with pulsed electric fields
Timothy J. O'Brien, Santa Clara, CA (US); Quim Castellvi, Barcelona (ES); Luis L. Mangual Arbelo, Sunnyvale, CA (US); Jonathan R. Waldstreicher, West Orange, NJ (US); Seth S. Gleiman, Guilford, CT (US); Nicholas S. Mercer, San Francisco, CA (US); Kevin J Taylor, San Mateo, CA (US); Robert E. Neal, II, Redwood City, CA (US); William S. Krimsky, Forest Hill, MD (US); and Armaan G. Vachani, Foster City, CA (US)
Assigned to Galvanize Therapeutics, Inc., San Carlos, CA (US)
Filed by Galvanize Therapeutics, Inc., San Carlos, CA (US)
Filed on Jan. 13, 2022, as Appl. No. 17/575,500.
Application 17/575,500 is a continuation of application No. PCT/US2020/042260, filed on Jul. 16, 2020.
Claims priority of provisional application 62/874,605, filed on Jul. 16, 2019.
Prior Publication US 2022/0133401 A1, May 5, 2022
Int. Cl. A61B 18/14 (2006.01); A61B 18/00 (2006.01)
CPC A61B 18/1482 (2013.01) [A61B 18/1492 (2013.01); A61B 2018/00041 (2013.01); A61B 2018/00083 (2013.01); A61B 2018/0022 (2013.01); A61B 2018/00559 (2013.01); A61B 2018/00577 (2013.01); A61B 18/1477 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for treating an area of tissue suffering from dysplasia or cancer within a reproductive system of a patient comprising:
a catheter comprising an elongate shaft and an energy delivery body disposed near a distal end of the elongate shaft, wherein the elongate shaft is configured to be advanced into a luminal structure of the reproductive system so as to position the energy delivery body near or against the area of tissue suffering from dysplasia or cancer within the reproductive system; and
a generator couplable with the catheter, wherein the generator includes at least one energy delivery algorithm configured to be capable of providing an electric signal of energy at a depth of 2 mm and less into a wall of the luminal structure, wherein the energy is deliverable by the energy delivery body so as to treat the area of tissue suffering from dysplasia or cancer at a depth of up to 2 mm, wherein the energy comprises non-thermal energy and treating the area of tissue suffering from dysplasia or cancer comprises destroying at least a portion of cells suffering from dysplasia or cancer within the area of tissue while maintaining its collagen structure.