| CPC A61B 18/1206 (2013.01) [A61B 18/1492 (2013.01); A61N 1/06 (2013.01); A61B 2017/00867 (2013.01); A61B 2017/320069 (2017.08); A61B 2018/00029 (2013.01); A61B 2018/00345 (2013.01); A61B 2018/00357 (2013.01); A61B 2018/00375 (2013.01); A61B 2018/00404 (2013.01); A61B 2018/00434 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/00613 (2013.01); A61B 2018/00642 (2013.01); A61B 2018/00702 (2013.01); A61B 2018/00791 (2013.01); A61B 2018/00797 (2013.01); A61B 2018/00916 (2013.01); A61B 2018/00988 (2013.01); A61B 2018/124 (2013.01); A61B 2018/1407 (2013.01); A61B 2018/144 (2013.01); A61B 2018/1467 (2013.01); A61B 2218/002 (2013.01)] | 36 Claims |

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1. A method of performing pulmonary artery denervation, said method comprising:
(a) providing an ablation device to a user;
(b) providing computer executable instructions to the ablation device to:
(i) ablate target tissue in a pulmonary artery trunk under conditions effective to affect a reduction in mean pulmonary artery pressure of the patient when at least one ablation element of the ablation device is positioned within or in proximity to the pulmonary artery trunk of a patient, the pulmonary artery trunk including a distal portion of a main pulmonary artery, a proximal portion of a left pulmonary artery, and a proximal portion of a right pulmonary artery,
wherein the target tissue is in a portion of the pulmonary artery trunk proximal to a left side lateral wall at the distal portion of the main pulmonary artery and proximal to a lower wall of the proximal portion of the left pulmonary artery, and
wherein the conditions effective to affect the reduction in mean pulmonary artery pressure also affect a reduction in systolic pulmonary artery pressure, and
(ii) modify at least one ablation parameter for ablation of the target tissue in response to feedback from at least one sensor of the ablation device; and
(c) subsequent to (b), ablating the target tissue with the ablation device.
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