| CPC A61B 5/1495 (2013.01) [A61B 5/0017 (2013.01); A61B 5/7246 (2013.01); A61B 2560/0228 (2013.01); A61B 2560/0238 (2013.01)] | 27 Claims |

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1. A method comprising:
receiving sensor data conveyed by an analyte sensor comprising an analyte indicator;
using the sensor data to calculate one or more analyte levels;
receiving one or more reference analyte level measurements;
using the sensor data, the one or more calculated analyte levels, and/or the one or more reference analyte level measurements to calculate a degradation rate of the analyte indicator of the analyte sensor; and
setting a dynamic calibration frequency based on the calculated degradation rate, wherein setting the dynamic calibration frequency based on the calculated degradation rate comprises:
determining whether the calculated degradation rate is below a first degradation rate threshold; and
setting the dynamic calibration frequency based on whether the calculated degradation rate is determined to be below the first degradation rate threshold.
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