US 12,458,244 B2
System and method for magnetic resonance neurography using intravenous ultrasmall supraparamagnetic iron oxide particles
Darryl B. Sneag, Plainview, NY (US); and Ek Tsoon Tan, Westbury, NY (US)
Assigned to NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY, New York, NY (US)
Appl. No. 18/043,264
Filed by NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY, New York, NY (US)
PCT Filed Sep. 3, 2021, PCT No. PCT/US2021/049042
§ 371(c)(1), (2) Date Feb. 27, 2023,
PCT Pub. No. WO2022/051611, PCT Pub. Date Mar. 10, 2022.
Claims priority of provisional application 63/074,911, filed on Sep. 4, 2020.
Prior Publication US 2023/0320612 A1, Oct. 12, 2023
Int. Cl. A61B 5/00 (2006.01); A61B 5/055 (2006.01); G01R 33/48 (2006.01); G01R 33/56 (2006.01)
CPC A61B 5/055 (2013.01) [G01R 33/4822 (2013.01); G01R 33/5601 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for imaging one or more peripheral nerves in an anatomical region of a subject, which method comprises:
introducing into a subject a dose of an iron-based contrast agent sufficient to cause a reduction of a T2 relaxation time of the subject's blood; and
acquiring, from a magnetic resonance imaging (MRI) scanner, one or more MRI images of the anatomical region of the subject that includes the one or more peripheral nerves and at least one vessel, wherein the anatomical region has been impacted by the dose of the iron-based contrast agent, wherein the one or more MRI images are more sensitive to mobile water molecules than immobile water molecules, and wherein the one or more MRI images delineate the one or more peripheral nerves more conspicuously than the subject's blood contained in the at least one vessel adjacent to the one or more peripheral nerves.