US 12,458,241 B2
Monitoring treatment of peripheral artery disease (PAD) using diffuse optical imaging
Andreas H. Hielscher, Brooklyn, NY (US); Christopher J. Fong, New York, NY (US); Jennifer Hoi, Belmont, CA (US); Hyun K. Kim, Cresskill, NJ (US); and Michael Khalil, Miami Lake, FL (US)
Assigned to The Trustees of Columbia University in the City of New York, New York, NY (US)
Filed by The Trustees of Columbia University in the City of New York, New York, NY (US)
Filed on May 7, 2024, as Appl. No. 18/657,003.
Application 18/657,003 is a continuation of application No. 17/881,844, filed on Aug. 5, 2022, granted, now 11,992,301.
Application 17/881,844 is a continuation of application No. 16/093,775, granted, now 11,439,312, issued on Sep. 13, 2022, previously published as PCT/US2017/029027, filed on Apr. 23, 2017.
Claims priority of provisional application 62/417,741, filed on Nov. 4, 2016.
Claims priority of provisional application 62/326,822, filed on Apr. 24, 2016.
Prior Publication US 2024/0398249 A1, Dec. 5, 2024
Int. Cl. A61B 5/05 (2021.01); A61B 5/00 (2006.01); A61B 5/02 (2006.01); A61B 5/021 (2006.01); A61B 5/022 (2006.01); A61B 5/0225 (2006.01); A61B 5/0245 (2006.01); A61B 5/026 (2006.01); A61B 5/1455 (2006.01)
CPC A61B 5/0261 (2013.01) [A61B 5/00 (2013.01); A61B 5/0073 (2013.01); A61B 5/0075 (2013.01); A61B 5/02 (2013.01); A61B 5/02007 (2013.01); A61B 5/021 (2013.01); A61B 5/022 (2013.01); A61B 5/02255 (2013.01); A61B 5/0245 (2013.01); A61B 5/1455 (2013.01); A61B 5/6828 (2013.01); A61B 5/6829 (2013.01); A61B 5/6831 (2013.01); A61B 5/6884 (2013.01); A61B 5/7425 (2013.01); A61B 2560/0437 (2013.01); A61B 2562/04 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A diffuse optical imaging apparatus comprising:
a substrate having a front face;
a plurality of light sources mounted to the substrate and aimed in a forward direction with respect to the front face, wherein at least a portion of each of the plurality of light sources is disposed in front of the front face, and wherein each of the plurality of light sources has a different wavelength;
a plurality of light detectors mounted to the substrate and aimed to detect light arriving from in front of the front face, wherein at least a portion of each of the plurality of light detectors is disposed in front of the front face;
a pad shaped and dimensioned to sit in front of the front face, the pad having at least one opening shaped and dimensioned to accommodate (a) portions of each of the plurality of light sources that are disposed in front of the front face and (b) portions of each of the plurality of light detectors that are disposed in front of the front face, wherein the pad has a front surface shaped and dimensioned for contacting a person's skin; and
a plurality of electrical conductors that (i) convey electrical signals that drive the plurality of light sources and (ii) convey electrical signals representative of the light detected by the plurality of light detectors.