	US 12,458,052 B2
	Human milk oligosaccharides for use in enhancing executive function
Bruce McConnell, La Tour de Peilz (CH); Louise Kristine Vigsnæs, Copenhagen NV (DK); Jonas Hauser, Lausanne (CH); and Nora Schneider, Les Monts-de-Corsier (CH)
Assigned to Glycom A/S, Hørsholm (DK)
Appl. No. 17/435,944
Filed by Glycom A/S, Hørsholm (DK)
PCT Filed Mar. 5, 2020, PCT No. PCT/IB2020/051904 § 371(c)(1), (2) Date Sep. 2, 2021, PCT Pub. No. WO2020/178774, PCT Pub. Date Sep. 10, 2020.
Claims priority of application No. 19160876 (EP), filed on Mar. 5, 2019; application No. 19161023 (EP), filed on Mar. 6, 2019; application No. PA 2019 01446 (DK), filed on Dec. 9, 2019; and application No. 19214414 (EP), filed on Dec. 9, 2019.
Prior Publication US 2022/0160013 A1, May 26, 2022
Int. Cl. A23L 33/00 (2016.01); A23L 33/125 (2016.01); A61K 31/702 (2006.01); A61P 25/28 (2006.01)

CPC A23L 33/40 (2016.08) [A23L 33/125 (2016.08); A61K 31/702 (2013.01); A61P 25/28 (2018.01)]

6 Claims

1. A method for enhancing executive function, the method comprising:

providing to a non-infant human, a composition formulated to enhance working memory performance in the non-infant human, the composition consisting essentially of a prebiotic mixture of synthetic human milk oligosaccharides (HMOs) selected from the group consisting of:

a mixture of the following four HMOs: 2′-fucosyllactose (2′-FL), difucosyllactose (DFL), lacto-N-tetraose (LNT), and lacto-N-neotetraose (LNnT), and

a mixture of the following six HMOs: 2′-FL, DFL, LNT, LNnT, 3′-sialyllactose (3′-SL), and 6′-sialyllactose (6′-SL);

providing instructions to the non-infant human indicating a dosage of the prebiotic mixture of synthetic HMOs to be consumed by the non-infant human, wherein the dosage is from about 0.5 g to about 15 g per day; and

enhancing working memory performance in the non-infant human consuming the indicated dosage of the mixture of synthetic HMOs, wherein enhancing working memory performance refers to enhancing the capacity to temporarily hold and manipulate information for completing cognitive tasks, including planning, problem solving, and/or decision making.