US 12,130,269 B2
Fast startup ion chromatography system and methods
Kannan Srinivasan, Tracy, CA (US); Mrinal Sengupta, Fremont, CA (US); Yan Liu, Palo Alto, CA (US); Christopher A. Pohl, Union City, CA (US); and Nebojsa Avdalovic, Cupertino, CA (US)
Assigned to Dionex Corporation, Sunnyvale, CA (US)
Filed by DIONEX CORPORATION, Sunnyvale, CA (US)
Filed on Aug. 27, 2021, as Appl. No. 17/459,757.
Application 17/459,757 is a continuation of application No. 15/729,480, filed on Oct. 10, 2017, granted, now 11,105,782.
Prior Publication US 2021/0389289 A1, Dec. 16, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 30/96 (2006.01); B01D 15/36 (2006.01); G01N 30/28 (2006.01)
CPC G01N 30/96 (2013.01) [B01D 15/362 (2013.01); B01D 15/367 (2013.01); G01N 2030/285 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A method of inhibiting translocation of an eluent in a liquid source through an ion exchange barrier of an ion exchange chromatography system, the method comprising:
applying a voltage or current across a first electrode and a second electrode, the voltage or current having a first polarity, the first electrode being disposed on a first side of the ion exchange barrier, the second electrode being disposed on a second side of the ion exchange barrier, the applied voltage or current with the first polarity electrolytically generating eluent ions at the second electrode and to generate a first electric field to promote the translocation of eluent counter ions towards the second electrode and through the ion exchange barrier from the first side to the second side, wherein the eluent counter ions and the eluent ions combine to form the eluent; and
selectively reversing a polarity of the voltage or current from the first polarity to a second polarity to generate a second electric field that inhibits translocation of the eluent towards the second electrode and through the ion exchange barrier from the first side to the second side, wherein the voltage or current having the first polarity is applied while flowing the liquid through an eluent generation chamber, wherein the voltage or current having the second polarity is applied while the flow of the liquid through the eluent generation chamber is stopped.