US 12,130,268 B2
System for electrospray ionization with integrated lc column and electrospray emitter
Brandon Howard Robson, San Jose, CA (US); Xuefei Sun, San Jose, CA (US); Carla Marie Medlin, Santa Clara, CA (US); and Shane Bechler, Menlo Park, CA (US)
Assigned to Dionex Corporation, Sunnyvale, CA (US)
Filed by DIONEX CORPORATION, Sunnyvale, CA (US)
Filed on Jun. 26, 2023, as Appl. No. 18/341,712.
Application 18/341,712 is a continuation of application No. 17/557,698, filed on Dec. 21, 2021.
Prior Publication US 2023/0341357 A1, Oct. 26, 2023
Int. Cl. G01N 30/00 (2006.01); G01N 30/60 (2006.01); G01N 30/72 (2006.01); H01J 49/04 (2006.01); H01J 49/16 (2006.01)
CPC G01N 30/7266 (2013.01) [G01N 30/6004 (2013.01); G01N 30/6047 (2013.01); H01J 49/0445 (2013.01); H01J 49/167 (2013.01)] 14 Claims
OG exemplary drawing
 
1. An integrated system for liquid separation and electrospray ionization, comprising:
an emitter-enabled capillary column including a column having an end pulled to a tip to implement an emitter, such that an emitter portion and a column portion are integrated into a single structure, and at least a portion of the emitter-enabled capillary coiled into a loop;
an outer electrically conductive sheath adapted for insertion within a holder having a high-voltage contact point, the electrically conductive sheath being adapted to contact the high-voltage contact point and provide an electrical connection to enable the emitter-enabled capillary column to receive a high voltage and wherein the electrically conductive sheath has a recess to receive the high-voltage contact point;
a fitting coupled to the emitter-enabled capillary column at an end distal from the emitter portion, the fitting adapted for connection to a liquid chromatography system, the fitting electrically contacts an eluent at the point the eluent enters the emitter-enabled capillary column; and
a conductive wire electrically coupling the electrically conductive sheath and the fitting.