	US 12,129,515 B2
	Detection of mutations regarding one or more deoxyribonucleic acid sequences using deterministic lateral displacement arrays
Stacey Gifford, Fairfield, CT (US); Benjamin Wunsch, Mt. Kisco, NY (US); Joshua T. Smith, Croton on Hudson, NY (US); and Sung-Cheol Kim, New York, NY (US)
Assigned to INTERNATIONAL BUSINESS MACHINES CORPORATION, Armonk, NY (US)
Filed by International Business Machines Corporation, Armonk, NY (US)
Filed on Oct. 14, 2021, as Appl. No. 17/501,019.
Application 17/501,019 is a continuation of application No. 16/007,389, filed on Jun. 13, 2018, granted, now 11,180,796.
Prior Publication US 2022/0033878 A1, Feb. 3, 2022
Int. Cl. C12Q 1/683 (2018.01); C12Q 1/6816 (2018.01)

CPC C12Q 1/683 (2013.01) [C12Q 1/6816 (2013.01); C12Q 2600/156 (2013.01)]

11 Claims

1. A method, comprising:

adding a first molecular probe to a sample of genetic material, wherein the first molecular probe binds to a target nucleic acid sequence;

hybridizing a second molecular probe to a reference nucleic acid sequence comprised within the sample of genetic material; and

screening for a mutation in the sample of genetic material by supplying the sample of genetic material to a nanoscale deterministic lateral displacement array to screen for a single nucleotide polymorphism, wherein the first molecular probe is smaller than a critical diameter for lateral displacement by the nanoscale deterministic lateral displacement array.