US 12,129,458 B2
Filter system for biopharmaceutical processes
Christian Manzke, Bovenden (DE)
Assigned to SARTORIUS STEDIM BIOTECH GMBH, Goettingen (DE)
Filed by Sartorius Stedim Biotech GmbH, Goettingen (DE)
Filed on Dec. 18, 2020, as Appl. No. 17/126,482.
Application 17/126,482 is a continuation of application No. PCT/EP2019/060872, filed on Apr. 29, 2019.
Claims priority of application No. 10 2018 004 890.0 (DE), filed on Jun. 19, 2018.
Prior Publication US 2021/0102154 A1, Apr. 8, 2021
Int. Cl. B01D 63/08 (2006.01); B01D 65/02 (2006.01); C12M 1/00 (2006.01); C12M 1/34 (2006.01)
CPC C12M 29/04 (2013.01) [B01D 63/081 (2013.01); B01D 63/082 (2013.01); B01D 63/084 (2013.01); B01D 65/022 (2013.01); C12M 23/40 (2013.01); C12M 41/00 (2013.01); B01D 2313/105 (2013.01); B01D 2313/18 (2013.01); B01D 2313/243 (2013.01); B01D 2321/346 (2013.01)] 19 Claims
OG exemplary drawing
 
1. Filter system for biopharmaceutical processes, said filter system comprising:
at least one filter unit; and
a distributor plate, against which the at least one filter unit directly rests and which comprises a distributor unit, which is arranged within the distributor plate and is fluidically connected via a fluid connection to the at least one filter unit;
wherein the distributor unit is configured to:
guide inflow fluid to be filtered from a fluid input port, through more than one inflow fluid opening of a fluid feed line fluidly connected to the fluid input port, to the at least one filter unit, and
receive and discharge the inflow fluid, once filtered, through more than one permeate discharge opening of at least two permeate discharge lines and more than one retentate discharge opening of at least one retentate discharge line, from the at least one filter unit,
wherein the distributor unit comprises at least one active control element, with which inflow fluid flow, which flows through the distributor unit and the at least one filter unit, is controlled in an open loop flow or in a closed loop flow,
wherein the distributor unit is tubeless,
wherein the fluid connection between the at least one filter unit and the distributor plate is tubeless,
wherein the at least one active control element is integrated in the distributor plate between the fluid input port and the inflow fluid openings of the fluid feed line and comprises a pump head configured to connect to a pump drive to pump the inflow fluid through the distributor plate and the at least one filter unit, and
wherein the inflow fluid openings and the permeate discharge openings are located on the distributor plate in one plane arranged along a line in alternating manner, and the retentate discharge openings and the permeate discharge openings are located on the distributor plate in one plane arranged along a line in alternating manner.