	US 12,129,311 B2
	Cyclic peptide combinatorial libraries
Predrag Cudic, Boca Raton, FL (US); and Jay McLaughlin, Gainesville, FL (US)
Assigned to FLORIDA ATLANTIC UNIVERSITY RESEARCH CORPORATION, Boca Raton, FL (US); and UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED, Gainesville, FL (US)
Filed by Florida Atlantic University Board of Trustees, Boca Raton, FL (US); and University of Florida Research Foundation, Gainesville, FL (US)
Filed on Feb. 10, 2023, as Appl. No. 18/167,333.
Application 18/167,333 is a division of application No. 16/257,580, filed on Jan. 25, 2019, granted, now 11,578,100.
Claims priority of provisional application 62/649,290, filed on Mar. 28, 2018.
Prior Publication US 2024/0132543 A1, Apr. 25, 2024
Int. Cl. A61K 31/4045 (2006.01); A61K 9/00 (2006.01); A61K 47/64 (2017.01); A61K 47/65 (2017.01); A61P 25/04 (2006.01); A61P 25/06 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/28 (2006.01); A61P 25/36 (2006.01); C07K 5/12 (2006.01); C07K 7/64 (2006.01); A61K 38/00 (2006.01); C40B 40/10 (2006.01)

CPC C07K 5/12 (2013.01) [A61K 9/0043 (2013.01); A61K 31/4045 (2013.01); A61K 47/64 (2017.08); A61K 47/65 (2017.08); A61P 25/04 (2018.01); A61P 25/06 (2018.01); A61P 25/16 (2018.01); A61P 25/18 (2018.01); A61P 25/28 (2018.01); A61P 25/36 (2018.01); C07K 7/64 (2013.01); A61K 38/00 (2013.01); C40B 40/10 (2013.01)]

3 Claims

1. A combinatorial library comprising a plurality of distinct cyclic peptides of

Formula II:

Tyr-Ala-Ser-Pro-Lys-cyclo-[Cys-Phe-Arg-XXXXX-Leu-Ala-Cys]-Thr (SEQ ID NO: 18), wherein each X is an amino acid selected from the group consisting of an D-amino acid, an L-amino acid, a non-natural synthetic amino acid, a naturally occurring amino acid, and a mixture thereof, said combinatorial library being free from amino acid sequence SEQ ID NO: 1, and

wherein each cyclic peptide of at least a portion of the cyclic peptides has an affinity for at least one opioid receptor and is an agonist or antagonist of the at least one opioid receptor.