US 12,129,288 B2
Polynucleotides heterodimers of soluble interferon receptors and uses thereof
James Arthur Posada, Miami, FL (US); and Pamela Smolak, Seattle, WA (US)
Assigned to Sanabio, LLC, Miami, FL (US)
Filed by Sanabio, LLC, Miami, FL (US)
Filed on Feb. 4, 2021, as Appl. No. 17/167,725.
Application 17/167,725 is a division of application No. 16/109,672, filed on Aug. 22, 2018, granted, now 10,947,295, issued on Mar. 16, 2021.
Claims priority of provisional application 62/548,737, filed on Aug. 22, 2017.
Prior Publication US 2021/0155673 A1, May 27, 2021
Int. Cl. C07K 14/715 (2006.01); A61K 38/00 (2006.01)
CPC C07K 14/7156 (2013.01) [A61K 38/00 (2013.01); C07K 2319/30 (2013.01)] 95 Claims
 
1. A composition comprising:
(a) a first nucleic acid molecule comprising a nucleotide sequence encoding a first polypeptide and a second nucleic acid molecule comprising a nucleotide sequence encoding a second polypeptide; or
(b) a nucleic acid molecule comprising a first nucleotide sequence encoding a first polypeptide and a second nucleotide sequence encoding a second polypeptide sequence;
wherein the first polypeptide sequence and second polypeptide sequence are selected from:
(i) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 40 and a second polypeptide comprising the amino acid sequence of SEQ ID NO: 43;
(ii) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 41 and a second polypeptide comprising the amino acid sequence of SEQ ID NO: 42;
(iii) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 53 and a second polypeptide comprising the amino acid sequence of SEQ ID NO: 55; and
(iv) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 57 and a second polypeptide comprising the amino acid sequence of SEQ ID NO: 59;
(v) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 40, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 43, SEQ ID NO: 55, and SEQ ID NO: 59;
(vi) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 43, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 40, SEQ ID NO: 53, and SEQ ID NO: 57;
(vii) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 42, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 41, SEQ ID NO: 45, and SEQ ID NO: 47;
(viii) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 41, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 42, SEQ ID NO: 49, and SEQ ID NO: 51;
(ix) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 53, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 43, SEQ ID NO: 55, and SEQ ID NO: 59;
(x) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 55, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 40, SEQ ID NO: 53, and SEQ ID NO: 57;
(xi) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 57, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 43, SEQ ID NO: 55, and SEQ ID NO: 59;
(xii) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 59, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 40, SEQ ID NO: 53, and SEQ ID NO: 57;
(xiii) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 45, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 42, SEQ ID NO: 49, and SEQ ID NO: 51;
(xiv) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 47, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 42, SEQ ID NO: 49, and SEQ ID NO: 51;
(xv) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 49, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 41, SEQ ID NO: 45, and SEQ ID NO: 47;
(xvi) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 51, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 41, SEQ ID NO: 45, and SEQ ID NO: 47;
(xvii) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 61, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 67, SEQ ID NO: 75, and SEQ ID NO: 82;
(xviii) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 63, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 65, SEQ ID NO: 73, and SEQ ID NO: 81;
(xix) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 65, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 63, SEQ ID NO: 71, and SEQ ID NO: 79;
(xx) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 67, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 61, SEQ ID NO: 69, and SEQ ID NO: 77;
(xxi) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 69, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 67, SEQ ID NO: 75, and SEQ ID NO: 82;
(xxii) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 71, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 65, SEQ ID NO: 73, and SEQ ID NO: 81;
(xxiii) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 73, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 63, SEQ ID NO: 71, and SEQ ID NO: 79;
(xxiv) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 75, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 61, SEQ ID NO: 69, and SEQ ID NO: 77;
(xxv) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 77, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 67, SEQ ID NO: 75, and SEQ ID NO: 82;
(xxvi) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 79, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 65, SEQ ID NO: 73, and SEQ ID NO: 81;
(xxvii) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 81, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 63, SEQ ID NO: 71, and SEQ ID NO: 79;
(xxviii) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 82, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 61, SEQ ID NO: 69, and SEQ ID NO: 77;
(xxix) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 84, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 89, SEQ ID NO: 97, and SEQ ID NO: 105;
(xxx) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 85, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 87, SEQ ID NO: 95, and SEQ ID NO: 103;
(xxxi) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 87, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 85, SEQ ID NO: 93, and SEQ ID NO: 101;
(xxxii) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 89, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 84, SEQ ID NO: 91, and SEQ ID NO: 99;
(xxxiii) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 91, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 89, SEQ ID NO: 97, and SEQ ID NO: 105;
(xxxiv) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 93, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 87, SEQ ID NO: 95, and SEQ ID NO: 103;
(xxxv) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 95, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 85, SEQ ID NO: 93, and SEQ ID NO: 101;
(xxxvi) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 97, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 84, SEQ ID NO: 91, and SEQ ID NO: 99;
(xxxvii) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 99, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 89, SEQ ID NO: 97, and SEQ ID NO: 105;
(xxxviii) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 101, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 87, SEQ ID NO: 95, and SEQ ID NO: 103;
(xxxix) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 103, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 85, SEQ ID NO: 93, and SEQ ID NO: 101; and
(xl) a first polypeptide comprising the amino acid sequence of SEQ ID NO: 105, and a second polypeptide comprising the amino acid sequence selected from SEQ ID NO: 84, SEQ ID NO: 91, and SEQ ID NO: 99.