US 12,129,282 B2
Factor H binding protein variants and methods of use thereof
Peter T. Beernink, Walnut Creek, CA (US)
Assigned to Children's Hospital & Research Center at Oakland, Oakland, CA (US)
Filed by Children's Hospital & Research Center at Oakland, Oakland, CA (US)
Filed on May 12, 2023, as Appl. No. 18/316,594.
Application 16/288,760 is a division of application No. 15/327,346, granted, now 10,266,572, issued on Apr. 23, 2019, previously published as PCT/US2015/041616, filed on Jul. 22, 2015.
Application 18/316,594 is a continuation of application No. 17/221,646, filed on Apr. 2, 2021, granted, now 11,673,920.
Application 17/221,646 is a continuation of application No. 16/600,282, filed on Oct. 11, 2019, granted, now 10,995,122, issued on May 4, 2021.
Application 16/600,282 is a continuation of application No. 16/288,760, filed on Feb. 28, 2019, granted, now 10,487,122, issued on Nov. 26, 2019.
Claims priority of provisional application 62/028,123, filed on Jul. 23, 2014.
Prior Publication US 2024/0025951 A1, Jan. 25, 2024
Int. Cl. A61K 39/095 (2006.01); A61K 39/00 (2006.01); C07K 14/22 (2006.01)
CPC C07K 14/22 (2013.01) [A61K 39/095 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/575 (2013.01)] 27 Claims
 
1. A variant factor H binding protein (fHbp), wherein the variant fHbp comprises:
an amino acid sequence at least 85% identical to the entire length of the amino acid sequence of fHbp ID 22 set forth in SEQ ID NO: 2; and
amino acid substitutions of lysine at position 219 with asparagine (K219N), leucine at position 130 with arginine (L130R), and glycine at position 133 with aspartic acid (G133D), each relative to the amino acid sequence set forth in SEQ ID NO:2, wherein the numbering of K219 is based on the numbering of amino acid residues in SEQ ID NO: 1.