US 12,129,275 B2
Neuroactive steroids, compositions, and uses thereof
Ravindra B. Upasani, San Jose, CA (US); Boyd L. Harrison, Princeton Junction, NJ (US); Benny C. Askew, Marshfield, MA (US); Jean-Cosme Dodart, Brookline, MA (US); Francesco G. Salituro, Marlborough, MA (US); and Albert Jean Robichaud, Boston, MA (US)
Assigned to SAGE THERAPEUTICS, INC., Cambridge, MA (US)
Filed by SAGE THERAPEUTICS, INC., Cambridge, MA (US)
Filed on Mar. 29, 2022, as Appl. No. 17/707,303.
Application 17/707,303 is a continuation of application No. 16/942,235, filed on Jul. 29, 2020, abandoned.
Application 16/942,235 is a continuation of application No. 16/114,791, filed on Aug. 28, 2018, granted, now 10,759,828, issued on Sep. 1, 2020.
Application 16/114,791 is a continuation of application No. 14/343,603, abandoned, previously published as PCT/US2012/054261, filed on Sep. 7, 2012.
Claims priority of provisional application 61/532,427, filed on Sep. 8, 2011.
Prior Publication US 2023/0192756 A1, Jun. 22, 2023
Int. Cl. C07J 41/00 (2006.01); C07J 1/00 (2006.01); C07J 3/00 (2006.01); C07J 7/00 (2006.01); C07J 9/00 (2006.01); C07J 31/00 (2006.01); C07J 43/00 (2006.01); C07J 75/00 (2006.01)
CPC C07J 41/00 (2013.01) [C07J 1/00 (2013.01); C07J 1/0029 (2013.01); C07J 3/00 (2013.01); C07J 7/007 (2013.01); C07J 9/00 (2013.01); C07J 9/005 (2013.01); C07J 31/003 (2013.01); C07J 31/006 (2013.01); C07J 41/0005 (2013.01); C07J 41/0011 (2013.01); C07J 41/0055 (2013.01); C07J 43/003 (2013.01); C07J 75/00 (2013.01)] 18 Claims
 
1. A compound of Formula (I-b1), (I-b2) or (I-b3):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof;
wherein:
Z is selected from the group consisting of

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry
R3b is hydrogen;
R3a is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl;
each instance of R2, R11a, and R11b is independently hydrogen or —ORB1, wherein RB1 is hydrogen or substituted or unsubstituted alkyl, or R11a and R11b are joined to form an oxo (═O) group; and
each of R6a and R6b is independently hydrogen, halo, or substituted or unsubstituted alkyl.