US 12,128,331 B2
Method for degassing a cross-flow diafiltration unit, cross-flow diafiltration method and cross-flow diafiltration unit
Martin Leuthold, Goettingen (DE); Alexander Helling, Goettingen (DE); and Ceren Gencoglu, Goettingen (DE)
Assigned to SARTORIUS STEDIM BIOTECH GMBH, Goettingen (DE)
Filed by SARTORIUS STEDIM BIOTECH GMBH, Goettingen (DE)
Filed on Mar. 28, 2022, as Appl. No. 17/705,907.
Application 17/705,907 is a continuation of application No. PCT/EP2020/075983, filed on Sep. 17, 2020.
Claims priority of application No. 10 2019 006 817.3 (DE), filed on Sep. 30, 2019.
Prior Publication US 2022/0212125 A1, Jul. 7, 2022
Int. Cl. B01D 61/10 (2006.01); B01D 19/00 (2006.01); B01D 63/08 (2006.01); B01D 65/02 (2006.01)
CPC B01D 19/0031 (2013.01) [B01D 61/10 (2013.01); B01D 63/08 (2013.01); B01D 65/022 (2013.01); B01D 2311/2657 (2013.01); B01D 2315/10 (2013.01); B01D 2315/16 (2013.01); B01D 2321/04 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A method for degassing a cross-flow diafiltration unit, comprising, in sequence:
(i) providing a cross-flow diafiltration unit having a diafiltration channel, a retentate channel and a permeate channel, a first filter material that delimits the diafiltration channel from the retentate channel, and a second filter material that delimits the retentate channel from the permeate channel; and
(ii) feeding a liquid into the retentate channel so that the liquid flows in a flow direction through the retentate channel and penetrates through the first filter material into the diafiltration channel, whereby the retentate channel and the diafiltration channel are filled with and degassed by the liquid.