	US 12,128,154 B2
	Filler comprising hyaluronic acid hydrogel having excellent filling properties
Cheol Jang, Daejeon (KR); Yeonsoo Kim, Daejeon (KR); Hyunsup Lee, Daejeon (KR); Myunghan Lee, Daejeon (KR); Ji Sun Kim, Daejeon (KR); Hyun Tae Jung, Daejeon (KR); Jineon So, Daejeon (KR); Chang Hyun Lee, Daejeon (KR); and Hwayoun Ree, Daejeon (KR)
Assigned to LG CHEM, LTD., Seoul (KR)
Appl. No. 17/311,229
Filed by LG CHEM, LTD., Seoul (KR)
PCT Filed Dec. 19, 2019, PCT No. PCT/KR2019/018129 § 371(c)(1), (2) Date Jun. 4, 2021, PCT Pub. No. WO2020/130685, PCT Pub. Date Jun. 25, 2020.
Claims priority of application No. 10-2018-0167782 (KR), filed on Dec. 21, 2018.
Prior Publication US 2022/0016313 A1, Jan. 20, 2022
Int. Cl. A61L 27/20 (2006.01); A61K 31/167 (2006.01); A61L 27/52 (2006.01)

CPC A61L 27/20 (2013.01) [A61K 31/167 (2013.01); A61L 27/52 (2013.01); A61L 2300/204 (2013.01); A61L 2300/402 (2013.01); A61L 2400/06 (2013.01); A61L 2430/34 (2013.01)]

11 Claims

1. A filler comprising a hyaluronic acid hydrogel,

wherein the hyaluronic acid hydrogel comprises a crosslinked hyaluronic acid obtained by crosslinking a hyaluronic acid having an average molecular weight of 2,000,000 Da to 4,000,000 Da, or a salt thereof with a crosslinking agent,

wherein the crosslinked hyaluronic acid is contained in an amount of about 1% to about 3% by weight based on the total weight of the filler,

wherein the hyaluronic acid hydrogel comprises the crosslinked hyaluronic acid particles with an average diameter of 300 to 500 μm, and wherein a wrinkle improvement efficiency (WIE) parameter in accordance with Equation 1 as a value for filling properties is 0.6 or more and 20 or less:

Wrinkle Improvement Efficiency (WIE) Parameter=([Average value of MSD slope]*[Absolute value of MSD at travel time of 0.1 s]*[Standard deviation of MSD slope value]*100)⁻¹ [Equation 1]

wherein in the Equation 1,

MSD refers to a mean square displacement for a plurality of tracer particles injected into the filler comprising a hyaluronic acid hydrogel at 1 vol %.