US 12,128,129 B2
Lactobacillus plantarum for skin care
Manuel Pesaro, Holzminden (DE); Dominik Stuhlmann, Holzminden (DE); Lisa Garbe, Holzminden (DE); Gerhard Schmaus, Höxter-Bosseborn (DE); Kerstin Holmgren, Helsingborg (SE); and Niklas Larsson, Lund (SE)
Assigned to SYMRISE AG, Holzminden (DE); and PROBI AB, Lund (SE)
Appl. No. 17/254,347
Filed by SYMRISE AG, Holzminden (DE); and PROBI AB, Lund (SE)
PCT Filed Jun. 26, 2019, PCT No. PCT/EP2019/067007
§ 371(c)(1), (2) Date Dec. 21, 2020,
PCT Pub. No. WO2020/002429, PCT Pub. Date Jan. 2, 2020.
Claims priority of application No. PCT/EP2018/067090 (WO), filed on Jun. 26, 2019.
Prior Publication US 2022/0233430 A1, Jul. 28, 2022
Int. Cl. A61K 8/99 (2017.01); A61G 19/00 (2006.01); A61K 8/02 (2006.01); A61K 9/14 (2006.01); A61K 35/747 (2015.01); A61P 17/00 (2006.01); A61P 29/00 (2006.01); A61Q 19/00 (2006.01)
CPC A61K 8/99 (2013.01) [A61G 19/00 (2013.01); A61K 8/0225 (2013.01); A61K 9/14 (2013.01); A61K 35/747 (2013.01); A61P 17/00 (2018.01); A61P 29/00 (2018.01)] 17 Claims
OG exemplary drawing
 
1. A method for improving the appearance of non-mucosal skin comprising topically applying to the non-mucosal skin a topical composition comprising:
(a) attenuated or dead Lactobacillus plantarum HEAL 19 (DSM 15313) having an intact physical structure,
wherein the Lactobacillus plantarum HEAL 19 (DSM 15313) have been heat-treated at a temperature of 60 to 121° C. for 1 second to 120 minutes;
(b) one or more carriers, excipients, further active ingredients, or a combination thereof;
(c) one or more preservatives; and
(d) water;
wherein the method improves the appearance of the non-mucosal skin by reducing or preventing skin irritation, dry skin, rash, acne, or skin aging.