US 12,128,115 B2
Compositions for chelating metals at low temperatures
Michael K. Schultz, Iowa City, IA (US); Christopher Pigge, Iowa City, IA (US); Mengshi Li, Iowa City, IA (US); Moustafa Gabr, Iowa City, IA (US); and Edwin Sagastume, Iowa City, IA (US)
Assigned to UNIVERSITY OF IOWA RESEARCH FOUNDATION, Iowa City, IA (US)
Appl. No. 17/051,037
Filed by UNIVERSITY OF IOWA RESEARCH FOUNDATION, Iowa City, IA (US)
PCT Filed Apr. 25, 2019, PCT No. PCT/US2019/029102
§ 371(c)(1), (2) Date Oct. 27, 2020,
PCT Pub. No. WO2019/240884, PCT Pub. Date Dec. 19, 2019.
Claims priority of provisional application 62/663,671, filed on Apr. 27, 2018.
Prior Publication US 2021/0228749 A1, Jul. 29, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 51/04 (2006.01); A61K 45/06 (2006.01); A61K 51/08 (2006.01)
CPC A61K 51/0482 (2013.01) [A61K 45/06 (2013.01); A61K 51/0497 (2013.01); A61K 51/083 (2013.01)] 7 Claims
 
1. A method of performing a chelating reaction comprising contacting a divalent metal with a compound of Formula (Ia):

OG Complex Work Unit Chemistry
or a salt thereof wherein:
each of R5-R12 is independently selected from the group consisting of H and -L-X;
Ra is selected from the group consisting of H and -L-X;
each L is independently selected from the group consisting of polyethylene glycol, an aliphatic chain, and a polypeptide; and
each X is a ligand, wherein the ligand is a peptide or a small molecule agent.