US 12,128,076 B2
Composition comprising probiotics and polypeptide having binding affinity for IgE and use thereof
Myoung Ho Jang, Seoul (KR); Young Chul Sung, Seoul (KR); and Zungyoon Yang, Incheon (KR)
Assigned to GI Innovation, Inc., Seoul (KR)
Appl. No. 16/959,016
Filed by GI INNOVATION, INC., Seoul (KR)
PCT Filed Jan. 14, 2019, PCT No. PCT/KR2019/000524
§ 371(c)(1), (2) Date Jun. 29, 2020,
PCT Pub. No. WO2019/139434, PCT Pub. Date Jul. 18, 2019.
Claims priority of application No. 10-2018-0004421 (KR), filed on Jan. 12, 2018.
Prior Publication US 2022/0347236 A1, Nov. 3, 2022
Int. Cl. A61K 35/745 (2015.01); A61K 9/00 (2006.01); A61K 9/14 (2006.01); A61K 9/19 (2006.01); A61K 35/744 (2015.01); A61K 35/747 (2015.01); A61K 38/17 (2006.01); A61K 39/395 (2006.01); A61P 37/08 (2006.01); C07K 14/735 (2006.01); C07K 16/42 (2006.01)
CPC A61K 35/745 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0056 (2013.01); A61K 9/14 (2013.01); A61K 9/19 (2013.01); A61K 35/744 (2013.01); A61K 35/747 (2013.01); A61K 38/1774 (2013.01); A61K 39/39566 (2013.01); A61P 37/08 (2018.01); C07K 14/70535 (2013.01); C07K 16/4291 (2013.01); C07K 2317/52 (2013.01); C07K 2317/60 (2013.01); C07K 2317/92 (2013.01); C07K 2319/30 (2013.01)] 6 Claims
OG exemplary drawing
 
1. A method for treating or preventing an allergic disease of a subject in need thereof, comprising:
a step of administering a probiotic to the subject; and
a step of administering a polypeptide dimer,
wherein the probiotic is Bifidobacterium longum,
wherein the polypeptide dimer comprises two monomers, each of which comprises an extracellular domain of an alpha subunit of an IgE Fc receptor (FcεRIαECD),
wherein each of the monomers comprises a modified Fc region,
and wherein the modified Fc region and the FcεRIαECD are linked via a hinge, and wherein the hinge is Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Xaa1 Xaa2 Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro (SEQ ID NO: 17) or Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Xaa3 Xaa4 Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro (SEQ ID NO: 18),
Xaa 1 and Xaa3 are Gly, and
Xaa2 and Xaa4 are Gly or Ser.