US 12,127,857 B2
Assisted screening of down syndrome skin prints based on machine learning algorithm
Sijia Wang, Shanghai (CN); and Jinxi Li, Shanghai (CN)
Assigned to SHANGHAI INSTITUTE OF NUTRITION AND HEALTH, CHINESE ACADEMY OF SCIENCES, Shanghai (CN)
Appl. No. 17/295,692
Filed by SHANGHAI INSTITUTE OF NUTRITION AND HEALTH, CHINESE ACADEMY OF SCIENCES, Shanghai (CN)
PCT Filed Nov. 20, 2019, PCT No. PCT/CN2019/119785
§ 371(c)(1), (2) Date May 20, 2021,
PCT Pub. No. WO2020/103881, PCT Pub. Date May 28, 2020.
Claims priority of application No. 201811384921.7 (CN), filed on Nov. 20, 2018.
Prior Publication US 2021/0386381 A1, Dec. 16, 2021
Int. Cl. A61B 5/00 (2006.01); A61B 5/1172 (2016.01); A61B 5/1174 (2016.01)
CPC A61B 5/7275 (2013.01) [A61B 5/0064 (2013.01); A61B 5/1172 (2013.01); A61B 5/1174 (2013.01); A61B 2503/04 (2013.01); A61B 2503/06 (2013.01)] 12 Claims
OG exemplary drawing
 
1. An early assisted screening system for Down syndrome, which comprises:
(a) a skin print feature input module, which is configured to input skin print features of a subject; wherein the skin print features comprise V7—pattern on the ball of right foot, V33—left hand atd angle, and V56—right hand D5R inter-finger fold(s);
(b) a processing module for diagnosis of Down syndrome based on skin print, wherein the processing module performs a scoring processing on the inputted skin print features according to a predetermined evaluation criteria to obtain a risk score, and compares the risk score with a Down syndrome risk threshold, thereby obtaining an assisted screening result; wherein, when the risk score is higher than the risk threshold, it indicates that the subject's risk of Down syndrome is higher than that of a normal population; and when the risk score is lower than the risk threshold, it indicates that the subject's risk of Down syndrome is lower than that of the normal population; and
(c) an output module for assisted screening result, which is configured to output the assisted screening result,
wherein in the processing, a risk score processing is performed as follows:
V7—pattern on the ball of right foot: when the arch print is present, the risk of disease increases;
V33—left hand atd angle: when the angle is greater than 50 degrees, the risk of disease increases; and
V56—D5R inter-finger fold: when there is only one inter-finger fold or the little finger is bent, the risk of disease increases.