US 12,127,779 B2
Methods, systems, and apparatuses for tissue ablation using a modulated exponential decay pulse
Enric Günther, Hattersheim (DE); Boris Rubinsky, El Cerrito, CA (US); Nina Klein, Friedrichsdorf (DE); Paul Mikus, Mission Viejo, CA (US); and Michael Stehling, Rödermark (DE)
Assigned to Inter Science GmbH, Gisikon (CH)
Appl. No. 17/273,302
Filed by Inter Science GmbH, Gisikon (CH)
PCT Filed Sep. 4, 2019, PCT No. PCT/US2019/049588
§ 371(c)(1), (2) Date Mar. 3, 2021,
PCT Pub. No. WO2020/051241, PCT Pub. Date Mar. 12, 2020.
Claims priority of provisional application 62/726,896, filed on Sep. 4, 2018.
Prior Publication US 2021/0330371 A1, Oct. 28, 2021
Int. Cl. A61B 18/12 (2006.01); A61B 18/00 (2006.01)
CPC A61B 18/1206 (2013.01) [A61B 2018/00577 (2013.01); A61B 2018/00613 (2013.01); A61B 2018/0072 (2013.01); A61B 2018/00767 (2013.01); A61B 2018/00791 (2013.01); A61B 2018/00827 (2013.01); A61B 2018/00875 (2013.01); A61B 2018/00892 (2013.01); A61B 2018/1246 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system comprising:
a waveform generator configured to generate a waveform comprising at least one of a voltage or a current, the waveform having an exponential decay;
a controller configured to modulate the waveform generated by the waveform generator to cause electroporation and electrolysis at an ablation target, wherein said modulate comprises interrupting delivery of the at least one of the voltage or the current to the ablation target during the exponential decay; and
an electrode electrically coupled to the waveform generator and configured to receive the waveform and deliver the at least one of the voltage or the current to the ablation target.