US 12,455,243 B2
Single-photon imaging system with reconfigurable controller for rapid switching between imaging modes
Rainer Daum, Gräfelfing (DE); and Bruce Pirger, Berkshire, NY (US)
Assigned to Life Technologies Corporation, Carlsbad, CA (US)
Appl. No. 18/032,331
Filed by FEI DEUTSCHLAND GMBH, Dreieich (DE)
PCT Filed Oct. 20, 2021, PCT No. PCT/IB2021/059629
§ 371(c)(1), (2) Date Apr. 17, 2023,
PCT Pub. No. WO2022/084858, PCT Pub. Date Apr. 28, 2022.
Claims priority of provisional application 63/094,135, filed on Oct. 20, 2020.
Prior Publication US 2023/0384225 A1, Nov. 30, 2023
Int. Cl. G01N 21/64 (2006.01); G01N 21/65 (2006.01)
CPC G01N 21/6458 (2013.01) [G01N 21/6408 (2013.01); G01N 21/65 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An imaging system configured to enable rapid switching between operational modes, the imaging system comprising:
an imaging system controller, the imaging system controller comprising
a reprogrammable logic device comprising memory, and
a high-speed data link;
optionally a suitable light source for fluorescence imaging;
an imaging sensor communicatively coupled to the controller; and
a host device communicatively coupled to the controller via the high-speed data link, the host device comprising one or more processors and one or more hardware storage devices having stored thereon computer-executable instructions that when executed by the one or more processors cause the host device to
instruct the imaging system controller to operate the imaging sensor according to a first operational mode,
receive imaging data from the imaging system controller during operation of the first operational mode,
reconfigure in real-time the reprogrammable logic device of the imaging system controller according to a second operational mode,
instruct the imaging system controller to operate the imaging sensor according to the second operational mode, the second operational mode differing from the first operational mode, wherein the second operational mode comprises a higher-speed photon counting mode, and
receive imaging data from the imaging system controller during operation of the second operational mode.