US 12,455,238 B2
Time delay integration acquisition for spatial genomics imaging
Joseph R. Johnson, Redwood City, CA (US); Ang Li, Santa Clara, CA (US); Jean Marc Fan Chung Tsang Min Ching, Sunnyvale, CA (US); and Mehdi Vaez-Iravani, Los Gatos, CA (US)
Assigned to Applied Materials, Inc., Santa Clara, CA (US)
Filed by Applied Materials, Inc., Santa Clara, CA (US)
Filed on Jul. 28, 2023, as Appl. No. 18/361,586.
Claims priority of provisional application 63/393,458, filed on Jul. 29, 2022.
Prior Publication US 2024/0035967 A1, Feb. 1, 2024
Int. Cl. G01N 21/47 (2006.01); G01N 21/64 (2006.01); H02K 15/60 (2025.01); H04N 25/711 (2023.01)
CPC G01N 21/4795 (2013.01) [G01N 21/6456 (2013.01); G01N 2021/6419 (2013.01); G01N 2021/6421 (2013.01); G01N 2021/6441 (2013.01); G01N 2021/6484 (2013.01); G01N 2201/0826 (2013.01); H02K 15/60 (2025.01); H04N 25/711 (2023.01)] 18 Claims
OG exemplary drawing
 
1. An imaging system for capturing spatial-omic images of biological tissue samples, the imaging system comprising:
an imaging chamber configured to secure a biological tissue sample placed in the imaging system;
a Time Delay and Integration (TDI) imager comprising a plurality of scan lines;
a light source and a fiber optic bundle comprising a plurality of fiber-optic lines, wherein each of the plurality of fiber-optic lines is configured to deliver light of different wavelengths to illuminate an area on the biological tissue sample that is being captured by a set of corresponding scan lines of the TDI imager; and
a controller configured to cause the TDI imager to scan the biological tissue sample using one or more TDI scans of the biological tissue sample.