US 12,454,704 B2
Efficient gene delivery tool with a wide therapeutic margin
Simko Sama, Berlin (DE); Alexander Weng, Berlin (DE); and Hardy Mitdank, Berlin (DE)
Assigned to FREIE UNIVERSITÄT BERLIN, Berlin (DE)
Appl. No. 17/787,296
Filed by FREIE UNIVERSITÄT BERLIN, Berlin (DE)
PCT Filed Dec. 17, 2020, PCT No. PCT/EP2020/086781
§ 371(c)(1), (2) Date Jun. 18, 2022,
PCT Pub. No. WO2021/122998, PCT Pub. Date Jun. 24, 2021.
Claims priority of application No. 19217512 (EP), filed on Dec. 18, 2019.
Prior Publication US 2023/0039644 A1, Feb. 9, 2023
Int. Cl. C12N 15/87 (2006.01); A61K 47/26 (2006.01); C07H 15/256 (2006.01)
CPC C12N 15/87 (2013.01) [A61K 47/26 (2013.01); C07H 15/256 (2013.01)] 12 Claims
 
1. A saponin according to formula (I):

OG Complex Work Unit Chemistry
wherein:
R1 is independent from other R1 residues in the same molecule H or an acetyl residue, with the proviso that at least two R1 residues are acetyl residues; and
R2 is independent from other R2 residues in the same molecule H or an acetyl residue, with the proviso that at least two R2 residues are acetyl residues.