US 12,454,590 B2
Hydrogel
Gianluca Andrea Artioli, Cambridge (GB); Andrew A. Brown, Cambridge (GB); Wayne N. George, Ilford (GB); Colin Pilkington, London (GB); Jem Pitcairn, Nottingham (GB); Alexandre Richez, Cambridge (GB); and Xavier von Hatten, Cambridge (GB)
Assigned to Ilumina Cambridge Limited, Cambridge (GB)
Appl. No. 17/600,072
Filed by ILLUMINA CAMBRIDGE LIMITED, Cambridge (GB)
PCT Filed Dec. 1, 2020, PCT No. PCT/EP2020/084163
§ 371(c)(1), (2) Date Sep. 29, 2021,
PCT Pub. No. WO2021/110700, PCT Pub. Date Jun. 10, 2021.
Claims priority of provisional application 62/942,527, filed on Dec. 2, 2019.
Claims priority of application No. 2024749 (NL), filed on Jan. 24, 2020.
Prior Publication US 2022/0185927 A1, Jun. 16, 2022
Int. Cl. C08F 220/56 (2006.01); C08F 2/38 (2006.01); C08F 220/60 (2006.01)
CPC C08F 220/603 (2020.02) [C08F 2/38 (2013.01); C08F 2438/03 (2013.01)] 17 Claims
 
1. A hydrogel, comprising:
a dendritic core formed from 3,5-Bis(2-dodecylthiocarbonothioylthio-1-oxopropoxy)benzoic acid, 1,1,1-Tris[(dodecylthiocarbonothioylthio)-2-methylpropionatelethane, or Pentaerythritol tetrakis[2-(dodecylthiocarbonothioylthio)-2-methylpropionate], wherein the dendritic core has from 2 arms to 30 arms;
a first acrylamide monomer incorporated into each arm of the dendritic core, the first acrylamide monomer having a structure:

OG Complex Work Unit Chemistry
wherein R1 and R2 are independently selected from the group consisting of an alkyl, an alkylamino, an alkylamido, an alkylthio, an aryl, a glycol, and optionally substituted variants thereof; and
a second acrylamide monomer incorporated into each arm of the dendritic core, the second acrylamide monomer having a structure:

OG Complex Work Unit Chemistry
wherein R3 is hydrogen or an alkyl; R4 is hydrogen or an alkyl; L is a linker including a linear chain of 2 atoms to 20 atoms wherein each atom is independently selected from the group consisting of carbon, oxygen, and nitrogen and optional substituents on any carbon and any nitrogen atoms in the chain; A is an N substituted amide having a structure

OG Complex Work Unit Chemistry
where R5 is hydrogen or an alkyl; E is a linear chain of 1 atom to 4 atoms wherein each atom is independently selected from the group consisting of carbon, oxygen and nitrogen, and optional substituents on any carbon and any nitrogen atoms in the chain; and Z is an optional nitrogen containing heterocycle.