US 12,454,574 B2
Anti-CD79B antibodies and chimeric antigen receptors and methods of use thereof
Fuliang Chu, Houston, TX (US); Sattva S. Neelapu, Houston, TX (US); JingJing Cao, Houston, TX (US); and Jingwei Liu, Houston, TX (US)
Assigned to BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Appl. No. 17/309,144
Filed by Board of Regents, The University of Texas System, Austin, TX (US)
PCT Filed Oct. 30, 2019, PCT No. PCT/US2019/058710
§ 371(c)(1), (2) Date Apr. 29, 2021,
PCT Pub. No. WO2020/092467, PCT Pub. Date May 7, 2020.
Claims priority of provisional application 62/752,889, filed on Oct. 30, 2018.
Prior Publication US 2021/0317209 A1, Oct. 14, 2021
Int. Cl. C07K 16/28 (2006.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07K 14/485 (2006.01); C07K 14/705 (2006.01); A61K 38/00 (2006.01)
CPC C07K 16/2803 (2013.01) [A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/421 (2025.01); A61K 40/4211 (2025.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07K 14/485 (2013.01); C07K 14/70503 (2013.01); A61K 38/00 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/48 (2023.05)] 46 Claims
 
1. An isolated monoclonal antibody, wherein the antibody specifically binds to CD79b and comprises:
(I):
(a) a first VH CDR is identical to SEQ ID NO: 3;
(b) a second VH CDR is identical to SEQ ID NO: 4;
(c) a third VH CDR is identical to SEQ ID NO: 5;
(d) a first VL CDR is identical to SEQ ID NO: 8;
(e) a second VL CDR is identical to SEQ ID NO: 9; and
(f) a third VL CDR is identical to SEQ ID NO: 10;
(II):
(a) a first VH CDR is identical to SEQ ID NO: 13;
(b) a second VH CDR is identical to SEQ ID NO: 14;
(c) a third VH CDR is identical to SEQ ID NO: 15;
(d) a first VL CDR is identical to SEQ ID NO: 18;
(e) a second VL CDR is identical to SEQ ID NO: 19; and
(f) a third VL CDR is identical to SEQ ID NO: 20; or
(III):
(a) a first VH CDR is identical to SEQ ID NO: 23;
(b) a second VH CDR is identical to SEQ ID NO: 24;
(c) a third VH CDR is identical to SEQ ID NO: 25;
(d) a first VL CDR is identical to SEQ ID NO: 28;
(e) a second VL CDR is identical to SEQ ID NO: 29; and
(f) a third VL CDR is identical to SEQ ID NO: 30.