US 12,454,571 B2
Biopharmaceutical compositions
Myrna A. Monck, Waltham, MA (US); Narendra B. Bam, King of Prussia, PA (US); Jennifer Dally, King of Prussia, PA (US); and Michelle Spatara, King of Prussia, PA (US)
Assigned to GLAXOSMITHLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED, Brentford (GB)
Filed by GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED, Middlesex (GB)
Filed on Aug. 5, 2022, as Appl. No. 17/881,988.
Application 16/806,071 is a division of application No. 15/754,768, granted, now 10,870,695, previously published as PCT/IB2016/055012, filed on Aug. 22, 2016.
Application 17/881,988 is a continuation of application No. 17/684,907, filed on Mar. 2, 2022, granted, now 11,459,384.
Application 17/684,907 is a continuation of application No. 17/373,537, filed on Jul. 12, 2021, granted, now 11,299,541.
Application 17/373,537 is a continuation of application No. 16/806,071, filed on Mar. 2, 2020, abandoned.
Claims priority of provisional application 62/249,497, filed on Nov. 2, 2015.
Claims priority of provisional application 62/247,906, filed on Oct. 29, 2015.
Claims priority of provisional application 62/240,131, filed on Oct. 12, 2015.
Claims priority of provisional application 62/209,000, filed on Aug. 24, 2015.
Prior Publication US 2022/0380452 A1, Dec. 1, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/24 (2006.01); A61P 11/02 (2006.01); A61P 11/06 (2006.01)
CPC C07K 16/244 (2013.01) [A61P 11/02 (2018.01); A61P 11/06 (2018.01); C07K 2317/24 (2013.01); C07K 2317/40 (2013.01); C07K 2317/90 (2013.01); C07K 2317/94 (2013.01)] 13 Claims
 
1. An aqueous liquid formulation comprising:
(a) 75 to 100 mg of an antibody comprising the heavy chain amino acid sequence of SEQ ID NO: 1 and the light chain amino acid sequence of SEQ ID NO: 2;
(b) a buffering agent selected from sodium phosphate dibasic heptahydrate, phosphate, citric acid, citrate, sodium phosphate, potassium phosphate, sodium citrate, histidine, or a combination thereof;
(c) pH between about 6.2 and 6.6
(d) sucrose in an amount ranging from 5% to 20% weight by volume
(e) polysorbate 80 in an amount ranging from 0.01% to 0.1% weight by volume; and
(f) EDTA in an amount ranging from 0.01 mM to 0.1 mM.