	US 12,454,557 B2
	Recombinant polypeptides for membrane fusion and uses thereof
Roy Duncan, Mineville (CA); Eileen Kathryn Clancy, San Francisco, CA (US); John Lewis, London (CA); Roberto Justo De Antueno, Halifax (CA); and Rae-Lynn Nesbitt, Port Stanley (CA)
Assigned to ENTOS PHARMACEUTICALS INC., Edmonton (CA)
Filed by ENTOS PHARMACEUTICALS INC., Edmonton (CA)
Filed on Sep. 19, 2022, as Appl. No. 17/933,193.
Application 17/933,193 is a continuation of application No. 16/245,381, filed on Jan. 11, 2019, granted, now 11,459,362.
Application 16/245,381 is a continuation of application No. 13/877,101, granted, now 10,227,386, previously published as PCT/CA2011/001088, filed on Sep. 29, 2011.
Claims priority of provisional application 61/471,445, filed on Apr. 4, 2011.
Claims priority of provisional application 61/438,155, filed on Jan. 31, 2011.
Claims priority of provisional application 61/387,726, filed on Sep. 29, 2010.
Prior Publication US 2023/0192783 A1, Jun. 22, 2023
Int. Cl. C07K 14/46 (2006.01); A61K 9/1271 (2025.01); C12N 15/113 (2010.01); C12N 15/11 (2006.01)

CPC C07K 14/46 (2013.01) [A61K 9/1271 (2013.01); C12N 15/113 (2013.01); C07K 2319/00 (2013.01); C07K 2319/03 (2013.01); C07K 2319/033 (2013.01); C07K 2319/33 (2013.01); C12N 15/111 (2013.01); C12N 2310/14 (2013.01); C12N 2320/32 (2013.01)]

16 Claims

1. A recombinant polypeptide for facilitating membrane fusion, said recombinant polypeptide comprising:

an ectodomain sequence comprising the sequence of SEQ ID NO: 19;

a p14 fusion-associated small transmembrane (FAST) protein transmembrane domain connected to the ectodomain sequence; and

an endodomain sequence connected to the transmembrane domain, and comprising a hydrophobic patch having the sequence of SEQ ID NO: 8.