US 12,454,528 B2
Process for the preparation of piperidine compounds
Alexander Michael Haydl, Ludwigshafen (DE); Michael Schmitt, Ludwigshafen (DE); Klaus Becker, Ludwigshafen (DE); Dirk Bethke, Ludwigshafen (DE); Elena Capito', Pontecchio Marconi (IT); and Johann-Peter Melder, Ludwigshafen (DE)
Assigned to BASF SE, Ludwigshafen (DE)
Appl. No. 17/785,828
Filed by BASF SE, Ludwigshafen (DE)
PCT Filed Dec. 14, 2020, PCT No. PCT/EP2020/085947
§ 371(c)(1), (2) Date Jun. 15, 2022,
PCT Pub. No. WO2021/122441, PCT Pub. Date Jun. 24, 2021.
Claims priority of application No. 19216493 (EP), filed on Dec. 16, 2019.
Prior Publication US 2023/0034961 A1, Feb. 2, 2023
Int. Cl. C07D 403/14 (2006.01)
CPC C07D 403/14 (2013.01) 18 Claims
 
1. A process for the preparation of a compound of formula

OG Complex Work Unit Chemistry
wherein R1 and R2 are independently from each other C1-C8alkyl, comprising reacting a compound of formula

OG Complex Work Unit Chemistry
with a formaldehyde source in presence of a palladium or platinum catalyst at a hydrogen pressure of 5×108 mPa to 200×108 mPa.