US 12,454,524 B2
(r)-n-(4-(chlorodifluoromethoxy)phenyl)-2-(difluoromethyl)-1-(1-hydroxypropan-2-yl)-7-(pyrimidin-5-yl)-1H-benzo[d]imidazole-5-carboxamide, or a pharmaceutically acceptable salt or tautomer thereof, for treating certain leukemias
F. Anthony Romero, Redwood City, CA (US); Thorsten A. Kirschberg, San Carlos, CA (US); Randall Halcomb, Foster City, CA (US); and Yingzi Xu, Palo Alto, CA (US)
Assigned to Terns Pharmaceuticals, Inc., Foster City, CA (US)
Filed by Terns Pharmaceuticals, Inc., Foster City, CA (US)
Filed on Mar. 6, 2025, as Appl. No. 19/072,824.
Application 19/041,557 is a division of application No. 18/339,516, filed on Jun. 22, 2023, granted, now 12,240,835, issued on Mar. 4, 2025.
Application 19/072,824 is a continuation of application No. 19/041,557, filed on Jan. 30, 2025.
Application 18/339,516 is a continuation of application No. 17/982,419, filed on Nov. 7, 2022, abandoned.
Application 17/982,419 is a continuation of application No. 17/711,894, filed on Apr. 1, 2022, abandoned.
Application 17/711,894 is a continuation of application No. 17/445,791, filed on Aug. 24, 2021, abandoned.
Application 17/445,791 is a continuation of application No. 17/145,163, filed on Jan. 8, 2021, abandoned.
Application 17/145,163 is a continuation of application No. 16/573,860, filed on Sep. 17, 2019, granted, now 10,889,571, issued on Jan. 12, 2021.
Claims priority of provisional application 62/889,929, filed on Aug. 21, 2019.
Claims priority of provisional application 62/816,637, filed on Mar. 11, 2019.
Claims priority of provisional application 62/733,029, filed on Sep. 18, 2018.
Prior Publication US 2025/0243184 A1, Jul. 31, 2025
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/506 (2006.01); A61P 35/00 (2006.01); C07D 235/16 (2006.01); C07D 239/28 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/04 (2006.01); C07D 417/04 (2006.01); C07D 471/04 (2006.01); C07D 498/04 (2006.01); C07D 513/04 (2006.01)
CPC C07D 403/04 (2013.01) [A61P 35/00 (2018.01); C07D 235/16 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01); C07D 417/04 (2013.01); C07D 471/04 (2013.01); C07D 498/04 (2013.01); C07D 513/04 (2013.01)] 30 Claims
 
1. A compound having Formula I:

OG Complex Work Unit Chemistry
 
2. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and the compound of claim 1.