	US 12,454,523 B2
	Pyrazole derivatives
Sally Elizabeth Russell, Bracknell (GB); and James Alan Morris, Bracknell (GB)
Assigned to SYNGENTA CROP PROTECTION AG, Basel (CH)
Filed by SYNGENTA CROP PROTECTION AG, Basel (CH)
Filed on May 17, 2023, as Appl. No. 18/319,066.
Application 18/319,066 is a division of application No. 17/161,788, filed on Jan. 29, 2021, granted, now 11,680,057.
Application 17/161,788 is a division of application No. 16/782,796, filed on Feb. 5, 2020, granted, now 11,059,806, issued on Jul. 13, 2021.
Claims priority of application No. 1901559 (GB), filed on Feb. 5, 2019.
Prior Publication US 2023/0286954 A1, Sep. 14, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 207/325 (2006.01); A01N 43/54 (2006.01); A01N 43/56 (2006.01); A01N 43/58 (2006.01); A01N 43/80 (2006.01); A01N 43/90 (2006.01); C07D 207/337 (2006.01); C07D 207/34 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 409/14 (2006.01); C07D 413/04 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01)

CPC C07D 403/04 (2013.01) [A01N 43/54 (2013.01); A01N 43/56 (2013.01); A01N 43/58 (2013.01); A01N 43/80 (2013.01); A01N 43/90 (2013.01); C07D 207/325 (2013.01); C07D 207/337 (2013.01); C07D 207/34 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01)]

9 Claims

1. A method, comprising:

reacting a compound of formula (X)

wherein ring A is a di- or tri-substituted pyrazole, substituted on one ring nitrogen by R^B2and substituted on at least one ring carbon by R^B3;

R^B2is C₁-C₃alkyl or C₁-C₃fluoroalkyl;

n is an integer of 1 or 2,

each R^B3is independently halogen, C₁-C₃haloalkoxy, C₁-C₃haloalkyl, C₁-C₃alkoxy, or C₁-C₃alkyl;

R^Q1and R^Q4are each hydrogen; and

R^Q2and R^Q3together with the carbon atoms to which they are joined form ring Q, which is an optionally substituted 5-membered thio-lactam ring;

to produce a pharmaceutical or agrochemical having a pyrazolo-pyrrolidone motif.