US 12,454,519 B2
Substituted N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)arylsulfonamide analogs as modulators of cereblon protein
Marcus Fisher, Memphis, TN (US); Fatemeh Keramatnia, Memphis, TN (US); Kevin Mcgowan, Memphis, TN (US); Jaeki Min, Memphis, TN (US); Gisele A. Nishiguchi, Memphis, TN (US); Jeanine Price, Memphis, TN (US); Zoran Rankovic, Memphis, TN (US); Sourav Das, Memphis, TN (US); Charles G. Mullighan, Memphis, TN (US); and Yunchao Chang, Memphis, TN (US)
Assigned to ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC., Memphis, TN (US)
Filed by ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC., Memphis, TN (US)
Filed on Sep. 14, 2023, as Appl. No. 18/368,497.
Application 18/368,497 is a continuation of application No. 17/740,148, filed on May 9, 2022.
Application 17/740,148 is a continuation of application No. PCT/US2021/051648, filed on Sep. 23, 2021.
Claims priority of provisional application 63/082,365, filed on Sep. 23, 2020.
Prior Publication US 2024/0132463 A1, Apr. 25, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 401/04 (2006.01); A61K 31/45 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01)
CPC C07D 401/04 (2013.01) [A61K 31/45 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61P 35/02 (2018.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01)] 26 Claims
 
1. A compound having a structure represented by a formula:

OG Complex Work Unit Chemistry
wherein n is an integer selected from 0, 1 and 2;
wherein each of A1 and A2 is independently selected from —(C═O)— and —CH2—, provided that at least one of A1 and A2 is —(C═O)—;
wherein each of R11 and R15 is hydrogen; and
wherein each of R12, R13, and R14 is independently selected from hydrogen, halogen, —SF5, —CN, —N3, —NH2, —OH, —CN, —SCF3, C1-C3 alkoxy, C1-C3 haloalkyl, C1-C3 aminoalkyl, C1-C3 alkylamino, C1-C3 hydroxyalkyl, —O—(C1-C3 haloalkyl), C3-C8 cycloalkyl, C1-C6 alkyl, and phenyl;
or a pharmaceutically acceptable salt thereof.