US 12,454,518 B2
Substituted N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)arylsulfonamide analogs as modulators of cereblon protein
Marcus Fischer, Memphis, TN (US); Fatemeh Keramatnia, Memphis, TN (US); Kevin Mcgowan, Memphis, TN (US); Jaeki Min, Memphis, TN (US); Gisele A. Nishiguchi, Memphis, TN (US); Jeanine Price, Memphis, TN (US); Zoran Rankovic, Memphis, TN (US); Sourav Das, Memphis, TN (US); Charles G. Mullighan, Memphis, TN (US); and Yunchao Chang, Memphis, TN (US)
Assigned to St. Jude Children's Research Hospital, Inc., Memphis, TN (US)
Filed by ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC., Memphis, TN (US)
Filed on May 9, 2022, as Appl. No. 17/740,148.
Application 17/740,148 is a continuation of application No. PCT/US2021/051648, filed on Sep. 23, 2021.
Claims priority of provisional application 63/082,365, filed on Sep. 23, 2020.
Prior Publication US 2022/0274948 A1, Sep. 1, 2022
Int. Cl. C07D 401/04 (2006.01); A61K 31/45 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01)
CPC C07D 401/04 (2013.01) [A61K 31/45 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61P 35/02 (2018.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01)] 29 Claims
 
1. A compound having a structure represented by a formula:

OG Complex Work Unit Chemistry
wherein n is an integer selected from 0, 1 and 2;
wherein each of A1 and A2 is independently selected from —(C═O)— and —CH2—, provided that at least one of A1 and A2 is —(C═O)—;
wherein R1 is selected from:
(a) a 5- to 10-membered aryl or heteroaryl optionally substituted with a group selected from halogen, —SF5, —CN, —N3, —NH2, —OH, —CN, —SCF3, C1-C3 alkoxy, C1-C3 haloalkyl, C1-C3 aminoalkyl, C1-C3 alkylamino, C1-C3 hydroxyalkyl, —O—(C1-C3 haloalkyl), C3-C8 cycloalkyl, C1-C6 alkyl, and phenyl; and
(b) a 5- to 10-membered cycloalkyl optionally substituted with a group selected from halogen, —SF5, —CN, —N3, —NH2, —OH, —CN, —SCF3, C1-C3 alkoxy, C1-C3 haloalkyl, C1-C3 aminoalkyl, C1-C3 alkylamino, C1-C3 hydroxyalkyl, —O—(C1-C3 haloalkyl), C3-C8 cycloalkyl, C1-C6 alkyl, and phenyl;
or a pharmaceutically acceptable salt thereof.