US 12,454,517 B2
Nicotine salts, co-crystals, and salt co-crystal complexes
Gary M. Dull, Lewisville, NC (US); Andrew Carr, Cambridge (GB); and Emma Sharp, Cambridgeshire (GB)
Assigned to R.J. Reynolds Tobacco Company, Winston-Salem, NC (US)
Filed by R.J. Reynolds Tobacco Company, Winston-Salem, NC (US)
Filed on Sep. 2, 2021, as Appl. No. 17/465,436.
Application 17/465,436 is a division of application No. 16/739,427, filed on Jan. 10, 2020, granted, now 11,136,305.
Application 16/739,427 is a continuation of application No. 15/671,722, filed on Aug. 8, 2017, granted, now 10,556,880, issued on Feb. 11, 2020.
Application 15/671,722 is a continuation of application No. 14/721,283, filed on May 26, 2015, granted, now 9,738,622, issued on Aug. 22, 2017.
Claims priority of provisional application 62/003,295, filed on May 27, 2014.
Prior Publication US 2021/0395219 A1, Dec. 23, 2021
Int. Cl. C07D 401/04 (2006.01); A24B 13/00 (2006.01); A24B 15/38 (2006.01); A24F 40/10 (2020.01); A24F 40/20 (2020.01); A61K 9/00 (2006.01); A61M 11/04 (2006.01); A61M 15/06 (2006.01); C07C 65/03 (2006.01); C07C 65/11 (2006.01)
CPC C07D 401/04 (2013.01) [A24B 13/00 (2013.01); A24B 15/38 (2013.01); A61K 9/0056 (2013.01); C07C 65/03 (2013.01); C07C 65/11 (2013.01); A24F 40/10 (2020.01); A24F 40/20 (2020.01); A61M 11/042 (2014.02); A61M 15/06 (2013.01); A61M 2205/8206 (2013.01); C07B 2200/13 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An electronic smoking article comprising an inhalable substance medium contained within a cartridge body and a heating member positioned to provide heat to at least a portion of the inhalable substance medium, wherein the inhalable substance medium comprises a salt of nicotine and 2,3-dihydroxybenzoic acid,
wherein the salt of nicotine and 2,3-dihydroxybenzoic acid is characterized by an X-ray powder diffraction pattern having peaks at one or more of the following 2-theta diffraction angles: 12.4, 12.5, 15.2, 18.3, 19.7, 20.3, 20.9, 24.9, 25.2, 26.5, and 30.4.