US 12,454,501 B2
Evolving random heteropolymers towards catalytically active materials
Alfredo Alexander-Katz, Cambridge, MA (US); Shayna Hilburg, Cambridge, MA (US); Ting Xu, Berkeley, CA (US); Hao Yu, Emeryville, CA (US); Stefan Marco Eres, Berkeley, CA (US); and Philjun Kang, Pleasanton, CA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US)
Appl. No. 18/720,968
Filed by MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US); and THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
PCT Filed Oct. 6, 2023, PCT No. PCT/US2023/076277
§ 371(c)(1), (2) Date Jun. 17, 2024,
PCT Pub. No. WO2024/123469, PCT Pub. Date Jun. 13, 2024.
Claims priority of provisional application 63/430,902, filed on Dec. 7, 2022.
Prior Publication US 2024/0417352 A1, Dec. 19, 2024
Int. Cl. C07C 29/14 (2006.01); B01J 31/06 (2006.01); C08F 220/14 (2006.01); C08F 220/18 (2006.01)
CPC C07C 29/14 (2013.01) [B01J 31/06 (2013.01); C08F 220/14 (2013.01); C08F 220/1808 (2020.02); B01J 2231/12 (2013.01); B01J 2231/4288 (2013.01); B01J 2231/62 (2013.01); B01J 2231/70 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A composition of biomimetic catalyst molecules comprising:
a mixture of heteropolymer sequences wherein a portion of the heteropolymers comprise a catalytically active region similar to that of a naturally occurring enzyme active site, wherein the catalytically active region catalyzes a reaction of a substrate in a manner functionally similar to that of a naturally occurring enzyme; and
wherein the portion of heteropolymers comprises a 3-dimensional configuration that mimics physicochemical properties of naturally occurring enzymes.