US 12,453,860 B2
Effective invasive multichannel desynchronizing stimulation
Peter Tass, Stanford, CA (US); and Justus Alfred Kromer, Stanford, CA (US)
Assigned to The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US)
Appl. No. 17/253,988
Filed by The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US)
PCT Filed Jun. 21, 2019, PCT No. PCT/US2019/038545
§ 371(c)(1), (2) Date Dec. 18, 2020,
PCT Pub. No. WO2019/246561, PCT Pub. Date Dec. 26, 2019.
Claims priority of provisional application 62/688,962, filed on Jun. 22, 2018.
Prior Publication US 2021/0268289 A1, Sep. 2, 2021
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01)
CPC A61N 1/36178 (2013.01) [A61N 1/0531 (2013.01); A61N 1/0534 (2013.01); A61N 1/0551 (2013.01); A61N 1/36064 (2013.01); A61N 1/36067 (2013.01)] 18 Claims
OG exemplary drawing
 
1. An apparatus for treatment of a patient using multichannel desynchronizing stimulation, comprising:
n stimulation contacts, with n being 3 or greater;
a signal generator connected to the n stimulation contacts; and
a controller connected to the signal generator to direct operation of the signal generator,
wherein the controller is configured to direct the signal generator to apply a sequence of a plurality of stimuli through the n stimulation contacts, such that inter-stimulation times between each successive individual stimulus of the plurality of stimuli through the n stimulation contacts in the sequence are time-varying, and successive stimuli in the sequence are non-overlapping in time,
wherein each stimulus comprises two or more bursts of multiple pulses respectively and simultaneously applied at two or more of the n stimulation contacts, and
wherein each stimulus has a duration defined by an onset of the burst to the end of the multiple pulses of the each stimulus, and
wherein the inter-stimulation times are defined by times between successive onsets of the bursts of the plurality of stimuli in the sequence, and
wherein the controller is configured to select the inter-stimulation times for the n stimulation contacts according to a common random process, and
wherein the controller is configured to select the inter-stimulation times according to a probability distribution associated with the random process, and
wherein the probability distribution is bounded by a lower threshold of the stimulus duration.