US 12,453,853 B2
Multi-modal stimulation for treating tremor
Kathryn H. Rosenbluth, San Francisco, CA (US); Scott Lee Delp, Stanford, CA (US); John Paderi, San Francisco, CA (US); Vijaykumar Rajasekhar, San Francisco, CA (US); Tahel Altman, San Francisco, CA (US); Samuel Richard Hamner, San Francisco, CA (US); and Erika Kristine Ross, San Mateo, CA (US)
Assigned to Cala Health, Inc., San Mateo, CA (US)
Filed by Cala Health, Inc., San Mateo, CA (US)
Filed on Jun. 27, 2018, as Appl. No. 16/020,876.
Application 16/020,876 is a continuation in part of application No. 15/277,946, filed on Sep. 27, 2016, granted, now 10,850,090.
Application 15/277,946 is a continuation of application No. 14/805,385, filed on Jul. 21, 2015, granted, now 9,452,287, issued on Sep. 27, 2016.
Application 14/805,385 is a continuation of application No. PCT/US2014/012388, filed on Jan. 21, 2014.
Claims priority of provisional application 61/857,248, filed on Jul. 23, 2013.
Claims priority of provisional application 61/822,215, filed on May 10, 2013.
Claims priority of provisional application 61/815,919, filed on Apr. 25, 2013.
Claims priority of provisional application 61/786,549, filed on Mar. 15, 2013.
Claims priority of provisional application 61/754,945, filed on Jan. 21, 2013.
Prior Publication US 2019/0001129 A1, Jan. 3, 2019
Int. Cl. A61N 1/36 (2006.01); A61N 1/02 (2006.01); A61N 1/04 (2006.01); A61N 1/08 (2006.01); A61N 1/18 (2006.01)
CPC A61N 1/36014 (2013.01) [A61N 1/025 (2013.01); A61N 1/0456 (2013.01); A61N 1/0476 (2013.01); A61N 1/0492 (2013.01); A61N 1/08 (2013.01); A61N 1/18 (2013.01); A61N 1/36067 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method of treating tremor in a subject, the method comprising:
applying a first stimulation from a first actuator to a first location on a body of the subject,
wherein the first location is a first skin surface of a wrist of the body,
wherein the first stimulation is therapeutically effective and comprises a current applied by electrical stimulation; and
applying a second stimulation from a second actuator to a second location on the body,
wherein the second location is a second skin surface of the wrist of the body,
wherein the second stimulation is therapeutically effective and comprises a plurality of vibratory stimulations,
wherein the second actuator comprises a phased array of piezoelectric elements;
wherein a first piezoelectric element of the phased array of piezoelectric elements is configured to vibrate at a first piezoelectric frequency of between about 20 kHz and about 2 MHz;
wherein a second piezoelectric element of the phased array of piezoelectric elements is configured to vibrate at a second piezoelectric frequency of between about 20 kHz and about 2 MHz;
wherein the first piezoelectric frequency is different than the second piezoelectric frequency;
wherein the first piezoelectric element is configured to vibrate at the first piezoelectric frequency for a first duration and the second piezoelectric element is configured to vibrate at the second piezoelectric frequency for a second duration,
wherein at least one of applying the first stimulation or applying the second stimulation is responsive to a controller in a smart device and based on a sensed amplitude of the tremor,
wherein, after applying the first stimulation and applying the second stimulation, the amplitude of the tremor is reduced,
wherein the first stimulation and the second stimulation both modulate one or more afferent nerves specifically associated with a peripheral pathway, and
wherein both the first actuator and the second actuator are coupled to the wrist of the body using a single flexible cuff.