US 12,453,810 B2
Dynamic adjustment of algorithms for separation and collection of blood components
Brian C. Case, Lake Villa, IL (US)
Assigned to Fenwal, Inc., Lake Zurich, IL (US)
Filed by Fenwal, Inc., Lake Zurich, IL (US)
Filed on Feb. 14, 2025, as Appl. No. 19/053,529.
Application 19/053,529 is a continuation of application No. 18/599,377, filed on Mar. 8, 2024, granted, now 12,257,378.
Application 18/599,377 is a continuation of application No. 17/019,397, filed on Sep. 14, 2020, granted, now 11,957,828, issued on Apr. 16, 2024.
Claims priority of provisional application 62/900,957, filed on Sep. 16, 2019.
Prior Publication US 2025/0186671 A1, Jun. 12, 2025
This patent is subject to a terminal disclaimer.
Int. Cl. A61M 1/36 (2006.01); B01D 21/26 (2006.01); B01D 21/30 (2006.01); B01D 63/16 (2006.01)
CPC A61M 1/3696 (2014.02) [B01D 21/262 (2013.01); B01D 21/30 (2013.01); B01D 63/16 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A blood separation device, comprising:
a separator configured to receive a blood separation chamber;
a pump system; and
a controller programmed with a blood separation algorithm for executing a blood separation procedure in which an initial target amount of blood from a blood source is pumped into the separator by the pump system and separated so as to collect a target yield of a target blood component, wherein the controller is configured to
access or receive results for a plurality of blood separation procedures executed by the blood separation device and/or by one or more other blood separation devices, with each of said results including an actual yield of said target blood component and/or a difference between a blood characteristic before and after execution of said blood separation procedure,
determine a correlation between said target and actual yields and/or said differences between the blood characteristic before and after execution of said blood separation procedure for a subset of said results so as to determine an adjusted amount of blood to be separated when subsequently executing said blood separation procedure and/or a scaling factor to be applied to said blood separation algorithm so as to separate the adjusted amount of blood when subsequently executing said blood separation procedure; and
modify said blood separation algorithm so as to separate the adjusted amount of blood when subsequently executing said blood separation procedure, with the controller being configured to employ machine learning techniques so as to minimize a mean squared error when correlating said target and actual yields and/or said differences between the blood characteristic before and after execution of said blood separation procedure.