US 12,453,804 B2
Hydrogel membrane for adhesion prevention
Christine E. Schmidt, Gainesville, FL (US); Scott A. Zawko, Austin, TX (US); and Sarah M. Mayes, Austin, TX (US)
Assigned to Board of Regents, the University of Texas System, Austin, TX (US)
Filed by Board of Regents, the University of Texas System, Austin, TX (US)
Filed on Jan. 26, 2023, as Appl. No. 18/159,756.
Application 18/159,756 is a continuation of application No. 16/952,155, filed on Nov. 19, 2020, granted, now 11,565,027.
Application 16/952,155 is a continuation of application No. 16/359,102, filed on Mar. 20, 2019, granted, now 10,850,011, issued on Dec. 1, 2020.
Application 16/359,102 is a continuation of application No. 15/597,541, filed on May 17, 2017, granted, now 10,272,184, issued on Apr. 30, 2019.
Application 15/597,541 is a continuation of application No. 14/758,873, granted, now 9,662,424, issued on May 30, 2017, previously published as PCT/US2013/074388, filed on Dec. 11, 2013.
Claims priority of provisional application 61/814,944, filed on Apr. 23, 2013.
Claims priority of provisional application 61/807,629, filed on Apr. 2, 2013.
Claims priority of provisional application 61/735,852, filed on Dec. 11, 2012.
Prior Publication US 2023/0173144 A1, Jun. 8, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 31/14 (2006.01); A61F 2/00 (2006.01); A61L 31/04 (2006.01); A61L 31/16 (2006.01); C08J 3/075 (2006.01); C08J 5/18 (2006.01)
CPC A61L 31/145 (2013.01) [A61F 2/0077 (2013.01); A61L 31/041 (2013.01); A61L 31/148 (2013.01); A61L 31/16 (2013.01); C08J 3/075 (2013.01); C08J 5/18 (2013.01); A61F 2002/009 (2013.01); C08J 2305/04 (2013.01); C08J 2405/08 (2013.01)] 17 Claims
 
1. A hydrogel composition comprising:
uncrosslinked hyaluronate;
crosslinked alginate and un-crosslinked alginate;
a crosslinker comprising: (a) a bound cation crosslinking the crosslinked alginate, and (b) an unbound cation configured to crosslink the un-crosslinked alginate; and
bound chelator and unbound chelator, the unbound chelator being configured to chelate the bound cation;
wherein the hydrogel composition is not templated with a crystal;
wherein the uncrosslinked hyaluronate, the crosslinked alginate, the un-crosslinked alginate, the crosslinker, the bound chelator, and the unbound chelator are simultaneously present in the hydrogel composition;
wherein the hydrogel composition is configured to increase in mucoadhesivity based on the unbound chelator chelating the bound cation and reducing mechanical integrity of the hydrogel composition.