	US 12,453,763 B2
	Human vaccine compositions and methods for treating leukemia
Karin Gaensler, Oakland, CA (US)
Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Appl. No. 17/600,588
Filed by The Regents of the University of California, Oakland, CA (US)
PCT Filed Apr. 3, 2020, PCT No. PCT/US2020/026615 § 371(c)(1), (2) Date Sep. 30, 2021, PCT Pub. No. WO2020/206282, PCT Pub. Date Oct. 8, 2020.
Claims priority of provisional application 62/829,874, filed on Apr. 5, 2019.
Prior Publication US 2022/0160852 A1, May 26, 2022
Int. Cl. A61K 39/00 (2006.01); A61K 35/13 (2015.01); A61K 35/15 (2025.01); A61K 38/20 (2006.01); A61K 40/00 (2025.01); A61K 40/10 (2025.01); A61K 40/19 (2025.01); A61K 40/24 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); C07K 14/005 (2006.01); C07K 14/54 (2006.01); C07K 14/705 (2006.01); C07K 14/715 (2006.01); C12N 5/09 (2010.01); C12N 5/10 (2006.01)

CPC A61K 39/001111 (2018.08) [A61K 39/0011 (2013.01); A61K 39/001119 (2018.08); A61K 39/00114 (2018.08); A61K 40/10 (2025.01); A61K 40/19 (2025.01); A61K 40/24 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2018.01); A61P 35/02 (2018.01); C07K 14/005 (2013.01); C07K 14/5443 (2013.01); C07K 14/70532 (2013.01); C07K 14/7155 (2013.01); A61K 2039/5152 (2013.01); A61K 2239/48 (2023.05)]

20 Claims

1. A nucleic acid molecule comprising a polycistronic expression cassette comprising:

a first coding sequence for a human co-stimulatory molecule CD80 (hCD80);

a second coding sequence for a human interleukin-15 (hIL-15); and

a third coding sequence for a human IL-15 receptor alpha (hIL-15Rα);

wherein the first coding sequence for hCD80 is operably positioned upstream to the second and the third coding sequences, and

wherein the first, second, and third coding sequences are linked to one another via a coding sequence for one or more autoproteolytic cleavage peptides.