US 12,453,759 B2
Di-thioester cationic lipids
Shrirang Karve, Lexington, MA (US); and Frank DeRosa, Lexington, MA (US)
Assigned to TRANSLATE BIO, INC., Waltham, MA (US)
Appl. No. 17/608,347
Filed by TRANSLATE BIO, INC., Lexington, MA (US)
PCT Filed May 1, 2020, PCT No. PCT/US2020/031000
§ 371(c)(1), (2) Date Nov. 2, 2021,
PCT Pub. No. WO2020/227085, PCT Pub. Date Nov. 12, 2020.
Claims priority of provisional application 62/842,848, filed on May 3, 2019.
Prior Publication US 2022/0257724 A1, Aug. 18, 2022
Int. Cl. A61K 38/45 (2006.01); A61K 9/127 (2025.01); A61K 38/17 (2006.01); A61K 48/00 (2006.01); C07C 327/30 (2006.01); C07C 329/16 (2006.01); C07D 295/15 (2006.01)
CPC A61K 38/45 (2013.01) [A61K 9/127 (2013.01); A61K 38/177 (2013.01); C07C 327/30 (2013.01); C07C 329/16 (2013.01); C07D 295/15 (2013.01); A61K 48/00 (2013.01)] 20 Claims
 
1. A cationic lipid having a structure selected from the group consisting of:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein
each R1 is independently C6-C30 aliphatic; and
each n is independently an integer of 1-12.