US 12,453,736 B2
Fragrance compositions and use thereof for improving sleep
Raphael K. L. Kang, Leonia, NJ (US); Alba T. Cilia, Township of Washington, NJ (US); and Louis J. Lombardo, Washingtonville, NY (US)
Assigned to TAKASAGO INTERNATIONAL CORPORATION, Tokyo (JP)
Appl. No. 17/041,214
Filed by TAKASAGO INTERNATIONAL CORPORATION, Tokyo (JP)
PCT Filed Apr. 1, 2019, PCT No. PCT/US2019/025257
§ 371(c)(1), (2) Date Sep. 24, 2020,
PCT Pub. No. WO2019/191782, PCT Pub. Date Oct. 3, 2019.
Claims priority of provisional application 62/650,510, filed on Mar. 30, 2018.
Prior Publication US 2021/0008082 A1, Jan. 14, 2021
Int. Cl. A61K 31/618 (2006.01); A61B 5/00 (2006.01); A61K 9/00 (2006.01); A61K 31/045 (2006.01); A61K 31/11 (2006.01); A61K 31/12 (2006.01); A61K 31/122 (2006.01); A61K 31/216 (2006.01); A61K 31/22 (2006.01); A61K 31/343 (2006.01); A61P 25/20 (2006.01)
CPC A61K 31/618 (2013.01) [A61B 5/0048 (2013.01); A61B 5/4812 (2013.01); A61K 9/0043 (2013.01); A61K 31/045 (2013.01); A61K 31/11 (2013.01); A61K 31/12 (2013.01); A61K 31/122 (2013.01); A61K 31/216 (2013.01); A61K 31/22 (2013.01); A61K 31/343 (2013.01); A61P 25/20 (2018.01)] 9 Claims
 
1. A method of improving at least one sleep parameter of a subject, wherein the method comprises:
providing a fragrance accord; and
administering the fragrance accord to the subject in an amount effective to improve the at least one sleep parameter;
wherein the fragrance accord comprises:
i) beta-ionone in an amount of from about 15% to about 30% by weight,
ii) at least one floral compound in an amount of from about 10% to about 60% by weight, and
iii) one musk compound, wherein the musk compound is selected from the group consisting of (3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyl-2,4,5,5a, 7,8,9,9b-octahydro-1H-benzo[e][1]benzofuran, 5-cyclohexadecen-1-one, L-muscone, (12E)-1-oxacyclohexadec-12-en-2-one, and 1,4-dioxacycloheptadecane-5,17-dione; and
wherein the at least one sleep parameter is selected from the group consisting of a decrease in number of total minutes awake, an increase in total minutes asleep, an increase in sleep efficiency, an increase in the number of REM sleep minutes, an increase in the number of light sleep minutes, and an increase in the number of deep sleep minutes.