US 12,453,728 B1
Compositions comprising inhibitors of microsomal triglyceride transfer protein and Apo-B secretion
Enoch Kim, Marblehead, MA (US); and Paul Sweetnam, Marblehead, MA (US)
Assigned to Redux Therapeutics, LLC, Marblehead, MA (US)
Filed by Redux Therapeutics, LLC, Marblehead, MA (US)
Filed on Jan. 14, 2025, as Appl. No. 19/020,126.
Application 19/020,126 is a continuation in part of application No. 18/798,201, filed on Aug. 8, 2024, abandoned.
Int. Cl. A61K 31/47 (2006.01); A61K 9/00 (2006.01); A61K 31/166 (2006.01); C07D 217/06 (2006.01)
CPC A61K 31/47 (2013.01) [A61K 9/0053 (2013.01); C07D 217/06 (2013.01)] 18 Claims
 
1. A composition comprising particles comprising a compound having the structure:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof;
wherein the compound is in crystalline form characterized by an x-ray powder diffraction (XRPD) diffractogram comprising characteristic peaks (°2θ) at angles of 9.267±0.2 (°2θ), 14.576±0.2 (°2θ), 19.506±0.2 (°2θ), and 26.132±0.2 (°2θ); and
wherein at least 50% of the particles are characterized by a volume particle fraction less than 10 μm.